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Dynamics of Immune Activation in Viral Diseases

  • Book
  • © 2020

Overview

Editors:
  1. Pallaval Veera Bramhachari

    1. Department of Biotechnology, Krishna University, Machilipatnam, India

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  • Reviews the role of the innate and adaptive immune response to viral infections

  • Introduces molecular markers for early diagnosis of viral infections

  • Highlights the role of DNA and RNA sensors in viral recognition

  • Present advances in the antiviral vaccine development

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xxiii
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  2. Role of Innate Immunity in Combating Viral Diseases

    1. Front Matter

      Pages 1-1
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    2. Significance and Dynamics of Immune Responses During Viral Pathogenesis

      • Pallaval Veera Bramhachari
      Pages 3-8

    3. Antibody-Dependent Enhancement of Viral Infections

      • Ruta Kulkarni
      Pages 9-41

    4. Inflammation During Virus Infection: Swings and Roundabouts

      • Sankar Bhattacharyya
      Pages 43-59

    5. Interferons and Their Role in Viral Infection

      • Suji George, Gururaj Rao Deshpande, Gajanan N. Sapkal
      Pages 61-80

    6. Role of Cytokines in Infectious Viral Disease

      • Pavani Sanapala, Sudhakar Pola
      Pages 81-98

    7. B Cells and Their Role in Combating Viral Diseases

      • Devanabanda Mallaiah, Pallaval Veera Bramhachari
      Pages 99-111

  3. Role of Adaptive Immunity in Combating Viral Diseases

    1. Front Matter

      Pages 113-113
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    2. Significant Role of Cellular Activation in Viral Infections

      • Bojjibabu Chidipi, Samuel Ignatious Bolleddu, Ganugula Mohana Sheela, Matta Reddy Alavala
      Pages 115-124

    3. Macrophages/Microvesicles and Their Task in Viral Diseases

      • Bojjibabu Chidipi, Samuel Ignatius, Madhavi Maddala, Pallaval Veera Bramhachari, Alavala Mattareddy
      Pages 125-137

    4. T Cells in Viral Infections: The Myriad Flavours of Antiviral Immunity

      • Achanta Jagadeesh, A. M. V. N. Prathyusha, Ganugula Mohana Sheela, Pallaval Veera Bramhachari
      Pages 139-148

    5. Potentiality of Toll-Like Receptors (TLRS) in Viral Infections

      • A. M. V. N. Prathyusha, Prudhvi Lal Bhukya, Pallaval Veera Bramhachari
      Pages 149-159

    6. Activation of Complement System During Viral Infections: Prospects and Future Challenges

      • Prudhvi Lal Bhukya, Pallaval Veera Bramhachari
      Pages 161-166

    7. MicroRNAs and Their Role in Viral Infection

      • Divya Tiraki
      Pages 167-186

    8. Evolution, Distribution, and Diversity of Immunodeficiency Viruses

      • Harika Sai Vemuri, Surekha Challa, Nageswara Rao Reddy Neelapu
      Pages 187-203

    9. Role of Immune Cells in Hepatitis B Infection

      • Prakriti Sinha, Parul Sahu
      Pages 205-227

    10. Significance of RNA Sensors in Activating Immune System in Emerging Viral Diseases

      • Preethika Nair, Siddhesh U. Sapre
      Pages 229-242

    11. Potentiality of DNA Sensors in Activating Immune System in Emerging Viral Infectious Diseases

      • Siddhesh U. Sapre, Preethika Nair
      Pages 243-260

    12. Advanced Immunotechnological Methods for Detection and Diagnosis of Viral Infections: Current Applications and Future Challenges

      • Pallaval Veera Bramhachari, Ganugula Mohana Sheela, A. M. V. N. Prathyusha, M. Madhavi, K. Satish Kumar, Neelapu Nageswara Rao Reddy et al.
      Pages 261-275
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Keywords

About this book

This book discusses various components of the innate and adaptive immune response in combating viral infections, presenting the recent advances in our understanding of innate immunity recognition of viruses and highlighting the important role of inflammation, cytokines such as interferon, toll-like receptors and leukocytes in the initial detection of invading viruses and subsequent activation of adaptive immunity.

It also summarizes the role of the adaptive immunity against viral infections through clearance of virus and establishment of memory response that protects against the recurrent infections. In addition, the book examines the role of DNA and RNA sensors in viral recognition and in controlling viral infection.

Lastly, it reviews the latest developments in the development of the rational viral vaccines. As such it is a useful resource book for postgraduate and early researchers wanting to gain insights into the immune response to viral infections.


Editors and Affiliations

  • Department of Biotechnology, Krishna University, Machilipatnam, India

    Pallaval Veera Bramhachari

About the editor

Dr. Pallaval Veera Bramhachari is currently Head of the Department of Biotechnology at Krishna University, India. He has served as a Postdoctoral Research Scientist at the Bacterial Pathogenesis Laboratory, Queensland Institute of Medical Research (QIMR), Australia, and DBT Postdoctoral Fellow at the Department of Microbiology and Cell Biology, Indian Institute of Science (IIsc), Bangalore. He holds a Ph.D. in Microbiology from Goa University, India. His research focuses on applied microbiology and cell biology research, including the biochemical mechanisms of bacterial-biofilm formation, structure-function relationship of bacterial rhamnolipids, and basic and translational cancer research. He has published more than 115 research articles in leading peer-reviewed international journals and 3 books, and has presented 47 abstracts at various national and international conferences. He has served as an editorial board member and reviewer for a number of national and international journals, and is a member of several international scientific societies and organizations, most importantly, the Indian Science Congress & Society of Biological Chemists, India. He has received a number of prestigious awards, notably, AP State Best Scientist Award 2017, DST SERB Young Scientist Award (2011) and was nominated as an Associate Fellow of Andhra Pradesh Academy of Sciences (APAS) for the year 2016.

Bibliographic Information

  • Book Title: Dynamics of Immune Activation in Viral Diseases

  • Editors: Pallaval Veera Bramhachari

  • DOI: https://doi.org/10.1007/978-981-15-1045-8

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2020

  • Hardcover ISBN: 978-981-15-1044-1Published: 25 February 2020

  • Softcover ISBN: 978-981-15-1047-2Published: 25 February 2021

  • eBook ISBN: 978-981-15-1045-8Published: 24 February 2020

  • Edition Number: 1

  • Number of Pages: XXIII, 283

  • Number of Illustrations: 1 b/w illustrations, 26 illustrations in colour

  • Topics: Immunology, Virology, Vaccine, Human Physiology

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