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  • © 2019

Brain Iron Metabolism and CNS Diseases

Editors:

  • Providing with an overall picture of brain iron metabolism and pathogenesis of CNS diseases
  • Introducing the cutting-edge developments in brain iron metabolism and related diseases
  • Illustrating the regulatory mechanisms of brain iron uptake, homeostasis and metabolism in pathophysiology and pharmacology of CNS disease models

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1173)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-ix
  2. Brain Iron Metabolism and CNS Diseases

    • Anand Thirupathi, Yan-Zhong Chang
    Pages 1-19
  3. Cellular Iron Metabolism and Regulation

    • Guofen Gao, Jie Li, Yating Zhang, Yan-Zhong Chang
    Pages 21-32
  4. Brain Iron Metabolism and Regulation

    • Peng Yu, Yan-Zhong Chang
    Pages 33-44
  5. Iron Pathophysiology in Parkinson Diseases

    • Hong Jiang, Ning Song, Qian Jiao, Limin Shi, Xixun Du
    Pages 45-66
  6. Iron Pathophysiology in Alzheimer’s Diseases

    • Tao Wang, Shuang-Feng Xu, Yong-Gang Fan, Lin-Bo Li, Chuang Guo
    Pages 67-104
  7. Iron Pathophysiology in Stroke

    • Mohammed M. A. Almutairi, Grace Xu, Honglian Shi
    Pages 105-123
  8. The Role of Iron in Amyotrophic Lateral Sclerosis

    • Xian-Le Bu, Yang Xiang, Yansu Guo
    Pages 145-152
  9. Iron Pathophysiology in Neurodegeneration with Brain Iron Accumulation

    • Sonia Levi, Anna Cozzi, Paolo Santambrogio
    Pages 153-177
  10. Diagnostics and Treatments of Iron-Related CNS Diseases

    • Huan Xiong, Qing-zhang Tuo, Yu-jie Guo, Peng Lei
    Pages 179-194

About this book

This book focuses on advances in our understanding of the regulatory mechanisms of brain iron uptake, iron homeostasis and iron metabolism in the pathophysiology and pharmacology of CNS disease models. Dysregulation of brain iron homeostasis can lead to severe pathological changes in the neural system. Iron deficiency can slow down the development of the neural system and cause language and motion disorders, while iron overload is closely related to neurodegenerative diseases. Although some current books include chapters on iron metabolism and certain neurodegenerative diseases, this is the first systematic summary of the latest discoveries regarding brain iron metabolism and CNS diseases.

By providing novel and thought-provoking insights into the mechanisms and physiological significance of brain iron metabolism and related diseases, the book stimulates further new research directions. It helps graduate students and researchers gain an overall picture of brain iron metabolism and the pathogenesis of neurodegenerative diseases, and also offers pharmaceutical companies inspiration for new treatment strategies for CNS diseases.


Editors and Affiliations

  • College of Life Sciences, Hebei Normal University , Shijiazhuang, China

    Yan-Zhong Chang

About the editor

Dr. Yan-Zhong Chang is a Professor, the Director of the Department of Physiology, and Dean of the College of Life Sciences, Hebei Normal University. He is a member of the Biophysical Society of China (BSC) committee, and the Associate Director of the Free Radical Biology and Biological Trace Element Branches of BSC, as well as of the Neuroendocrine and Metabolic Branch of the Chinese Society for Neuroscience (CSN). He also served as a member of the advisory board of Cellular and Molecular Life Sciences and of the editorial board of the Journal of Biochemical and Pharmacological Research. Prof. Chang’s research focuses on iron metabolism and related diseases, and he has published more than 100 articles in this field.


Bibliographic Information

  • Book Title: Brain Iron Metabolism and CNS Diseases

  • Editors: Yan-Zhong Chang

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-981-13-9589-5

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2019

  • Hardcover ISBN: 978-981-13-9588-8Published: 09 September 2019

  • Softcover ISBN: 978-981-13-9591-8Published: 09 September 2020

  • eBook ISBN: 978-981-13-9589-5Published: 27 August 2019

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: IX, 194

  • Number of Illustrations: 1 b/w illustrations, 5 illustrations in colour

  • Topics: Neurosciences, Human Physiology, Neurology

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access