Editors:
Reviews the mechanism of gliding motility in apicomplexan organisms
Discusses the structural, evolutionary, and functional role of actin-regulatory proteins
Introduces a mathematical model to help understand the role of actin-regulatory proteins in motility
Explores the potential of actin and its regulatory proteins as potential drug targets against apicomplexan organisms
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Table of contents (10 chapters)
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Front Matter
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Back Matter
About this book
This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements.
The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPα and CPβ), cyclase-associated protein (CAP) and coronin 13–24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design.
Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.
Editors and Affiliations
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School of Chemical Sciences, UM-DAE Centre for Excellence in Basic Sciences (CEBS), Mumbai, India
Avinash Kale
About the editor
Dr. Avinash Kale is a Reader at the School of Chemical Sciences, UM-DAE Centre for Excellence in Basic Sciences, Mumbai, India. His research interests are in the area of integrative structure biology and proteomics (ISBAP). He has more than 16 years of teaching experience in computational biology, biotechnology, molecular modeling and drug design, group theory, spectroscopy, and bioinformatics. He has served as a reviewer for a number of international journals, including the Journal of Biomolecular Structure and Dynamics (USA), and Nature Scientific Reports (USA).
Bibliographic Information
Book Title: Actin Polymerization in Apicomplexan
Book Subtitle: A Structural, Functional and Evolutionary Analysis
Editors: Avinash Kale
DOI: https://doi.org/10.1007/978-981-13-7450-0
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Singapore Pte Ltd. 2019
Hardcover ISBN: 978-981-13-7449-4Published: 26 November 2019
Softcover ISBN: 978-981-13-7452-4Published: 26 November 2020
eBook ISBN: 978-981-13-7450-0Published: 13 November 2019
Edition Number: 1
Number of Pages: XI, 101
Number of Illustrations: 11 illustrations in colour
Topics: Parasitology, Biomechanics, Protein Science, Protein Structure, Bioinformatics