Editors:
- Introduces readers to the biology of leukemia stem cells
- Emphasizes the necessity and importance of targeting LSCs in the treatment of hematopoietic malignancies
- Covers the molecular signatures of leukemia stem cells
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1143)
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Table of contents (10 chapters)
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Front Matter
About this book
This book introduces readers to the biology of leukemia stem cells (LSCs) and emphasizes the necessity and importance of targeting LSCs in the treatment of hematopoietic malignancies. It addresses the role of leukemia stem cells in different leukemia diseases and molecular signatures, as well as the metabolic and epigenetic regulation of leukemia stem cell function. With regard to solid tumors, a significant number of blood cancers are believed to be derived from leukemia stem cells (LSCs), which are responsible for disease progression, relapse and drug resistance. Consequently, new therapeutic strategies need to be developed by focusing on the complete eradication of LSCs. Given its scope, the book offers a valuable asset for graduate students and scientists in the fields of cell biology and cancer research etc.
Editors and Affiliations
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Medical Research Institute, Wuhan University, Wuhan, China
Haojian Zhang
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Department of Medicine, University of Massachusetts Medical School, Worcester, USA
Shaoguang Li
Bibliographic Information
Book Title: Leukemia Stem Cells in Hematologic Malignancies
Editors: Haojian Zhang, Shaoguang Li
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-981-13-7342-8
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2019
Hardcover ISBN: 978-981-13-7341-1Published: 05 August 2019
Softcover ISBN: 978-981-13-7344-2Published: 14 August 2020
eBook ISBN: 978-981-13-7342-8Published: 23 July 2019
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: VIII, 229
Number of Illustrations: 3 b/w illustrations, 37 illustrations in colour
Topics: Cancer Research, Stem Cells