Editors:
Reviews the effects and mechanisms of action of progranulin
Explores the value of progranulin as a therapeutic target
Discusses emerging treatment approaches for CNS disorders
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Table of contents (11 chapters)
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Front Matter
About this book
This book presents the latest knowledge on the roles of progranulin (PGRN) in normal physiology and pathology and explores the emerging significance of PGRN as a therapeutic target and biomarker in various CNS disorders, including frontotemporal lobe degeneration and other neurodegenerative diseases. Following initial recognition of the importance of PGRN in sexual differentiation of the developing brain and adult neurogenesis, it was subsequently discovered that PGRN acts as a chaperone of lysosomal enzymes and plays a crucial role in maintaining cellular protein homeostasis. It has also been found that sex steroids modulate the expression of PGRN and its trophic effects in the developing CNS and that PGRN directly or indirectly influences neural stem and progenitor cells. Against this background, deeper understanding of the molecular and functional properties of PGRN would provide fresh impetus for the development of mechanism-based therapeutic approaches for multiple disorders. Medications targeting the recovery of lysosomal function appear to hold particular promise in patients with neurodegenerative diseases resulting from PGRN insufficiency. In examining multiple aspects of this fascinating field, the book will be of high value for researchers and graduate students.
Editors and Affiliations
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Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan
Hideaki Hara, Shinsuke Nakamura
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Dementia Research Project, Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
Masato Hosokawa
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Department of Neurology, Gifu University Graduate School of Medicine, Gifu, Japan
Takayoshi Shimohata
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Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
Masugi Nishihara
About the editors
Hideaki Hara, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Japan
Masato Hosokawa, Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Japan
Shinsuke Nakamura, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Japan
Takayoshi Shimohata, Department of Neurology and Geriatrics, Gifu University Graduate School of Medicine, Japan
Masugi Nishihara, Department of Veterinary Physiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
Bibliographic Information
Book Title: Progranulin and Central Nervous System Disorders
Editors: Hideaki Hara, Masato Hosokawa, Shinsuke Nakamura, Takayoshi Shimohata, Masugi Nishihara
DOI: https://doi.org/10.1007/978-981-13-6186-9
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Singapore Pte Ltd. 2019
Hardcover ISBN: 978-981-13-6185-2Published: 02 April 2019
Softcover ISBN: 978-981-13-6188-3Published: 14 August 2020
eBook ISBN: 978-981-13-6186-9Published: 25 March 2019
Edition Number: 1
Number of Pages: VII, 183
Number of Illustrations: 24 b/w illustrations, 13 illustrations in colour
Topics: Gene Function, Molecular Medicine, Protein Science, Neurosciences