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Hearing Loss: Mechanisms, Prevention and Cure

  • Book
  • © 2019

Overview

Editors:
  1. Huawei Li

    1. Key Laboratory of Hearing Medicine of NHFPC, ENT Institute and Otorhinolaryngology Department, Shanghai Engineering Research Centre of Cochlear Implant, Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China

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  2. Renjie Chai

    1. MOE Key Laboratory for Developmental Genes and Human Disease, Institute of Life Sciences, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China

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  • Systematically introducing the pathogenesis, protection, the current and potential clinical treatments of hearing loss
  • Discussing cutting-edge developments in the basic research and medical treatments
  • With ample illustrations and tables

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1130)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-v
    Download chapter PDF

  2. Hair Cell Regeneration

    • Yan Chen, Shasha Zhang, Renjie Chai, Huawei Li
    Pages 1-16

  3. Protection of Hair Cells from Ototoxic Drug-Induced Hearing Loss

    • Jin Guo, Renjie Chai, Huawei Li, Shan Sun
    Pages 17-36

  4. Noise-Induced Cochlear Synaptopathy and Ribbon Synapse Regeneration: Repair Process and Therapeutic Target

    • Jian Wang, Shankai Yin, Hengchao Chen, Lijuan Shi
    Pages 37-57

  5. Protection and Prevention of Age-Related Hearing Loss

    • Zu-hong He, Ming Li, Sheng-yu Zou, Fu-ling Liao, Yan-yan Ding, Hong-guo Su et al.
    Pages 59-71

  6. Diagnosis, Intervention, and Prevention of Genetic Hearing Loss

    • Tao Yang, Luo Guo, Longhao Wang, Xiaoyu Yu
    Pages 73-92

  7. Protection of Spiral Ganglion Neurons and Prevention of Auditory Neuropathy

    • Wenwen Liu, Xue Wang, Man Wang, Haibo Wang
    Pages 93-107

  8. Advances in Understanding, Diagnosis, and Treatment of Tinnitus

    • Dongmei Tang, Huawei Li, Lin Chen
    Pages 109-128

  9. Cochlear Implantation and Rehabilitation

    • Fei Chen, Wenli Ni, Wenyan Li, Huawei Li
    Pages 129-144

  10. Non-implantable Artificial Hearing Technology

    • Ling Lu, Xiaoli Zhang, Xia Gao
    Pages 145-163

  11. Stem Cells: A New Hope for Hearing Loss Therapy

    • Yang Qiu, Jianhua Qiu
    Pages 165-180
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Keywords

About this book

This book systematically discusses the pathogenesis, prevention, and the current and potential clinical treatment of hearing loss, as well as the latest advances in hearing research. Hearing loss is a prevalent sensory disorder, which according to a 2015 World Health Organization (WHO) report affected 9% of the global population in 2015. As populations continue to age, more and more people are suffering from the condition, with 60% of those aged between 65 and 75 affected. Hearing loss seriously affects patients’ ability to work ability and quality of life, and as such deafness has become an increasingly urgent social problem around the globe. Sensorineural hearing loss is mainly caused by damage to the hair cells (HCs), and the subsequent loss of spiral ganglion neurons (SGNs). Damage to the HCs in the inner ear can result from exposure to loud noises and environmental and chemical toxins as well as genetic disorders, aging, and certain medications. This book provides ENT specialistsand researchers, as well as individuals affected a comprehensive introduction to the field of hearing loss.

Editors and Affiliations

  • Key Laboratory of Hearing Medicine of NHFPC, ENT Institute and Otorhinolaryngology Department, Shanghai Engineering Research Centre of Cochlear Implant, Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China

    Huawei Li

  • MOE Key Laboratory for Developmental Genes and Human Disease, Institute of Life Sciences, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China

    Renjie Chai

About the editors

Dr. Huawei Li, M.D. is a Professor, Chief Physician and doctoral and post doctoral mentor, and was appointed Chairman of the Department of Otorhinolaryngology Affiliated Eye and ENT Hospital in 2016. His other appointments include Vice-chairman of NHC Key Laboratory of Hearing Medicine, President of the Shanghai Otolaryngology Doctors’ Association, Vice-president of Shanghai Medical Association of Otolaryngology Head and Neck Surgey, member of the Chinese Medical Association of Otolaryngology Head and Neck Surgery. He is also Chief Scientist of 973 National Project of China and of the National Key R&D Program of China, Specially-appointed Professor in the Yangtze River Scholar Program, Laureate of National Outstanding Youth Science Fund, Shanghai Excellent Discipline Leaders, Visiting Professor of Massachusetts Eye and Ear Infirmary, Harvard Medical School. He has also received an honorary title for his outstanding contribution to NHC. His research focuses on otomicrosurgery, stem celltranscriptional regulation, and hair cell regeneration. He has published more than 100 papers, including in Nature Medicine and PNAS.

Dr. Renjie Chai, Ph.D., is a Professor and Assistant Dean of the Institute of Life Sciences, Southeast University. His other appointments include Vice-president of the Association of Hearing, Speech and Communication in Biophysical Society of China, executive board member of the International Association of Physicians in Audiology. He is the winner of the National Natural Science Foundation of China Excellent Youth Fund and of the 1000 Young Talents Recruitment Plan of China, and has been awarded more than 20 grants including the National Key R&D Program of China, the Strategic Priority Research Program of the Chinese Academy of Science, and a Faculty Research Award from Boehringer Ingelheim and Novartis. His research focuses on the regeneration and protection of inner ear hair cells and spiral ganglion neurons. Hehas published more than 70 papers, including in Advanced Materials, Nature Communications, and PNAS.


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