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  • © 2019

Models, Molecules and Mechanisms in Biogerontology

Physiological Abnormalities, Diseases and Interventions

Editors:

  • Elaborates on the different cellular, biochemical and molecular changes that occur during aging

  • Highlights the implications of aging on the nervous system

  • Recommends important remedies like dietary restrictions and natural products as anti-aging methods to adopt

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xi
  2. Alterations in Nervous System, Genes, Hormones and Immunity During Aging

    1. Front Matter

      Pages 1-1
    2. Neurological Problems of the Elderly

      • Laxmi Narayan Tripathy
      Pages 3-11
    3. Molecular Marker and Therapeutic Regimen for Neurodegenerative Diseases

      • Sharmistha Dey, Nitish Rai, Shashank Shekhar, Amrendra Pratap Singh, Vertica Agnihotri
      Pages 13-41
    4. Neurodegeneration During Aging: The Role of Oxidative Stress Through Epigenetic Modifications

      • Sweta Srivas, Meghraj Singh Baghel, Padmanabh Singh, Mahendra K. Thakur
      Pages 43-55
    5. Signaling of Nociceptors and Pain Perception: Impact of Age

      • Manjula Vinayak, Ajeet Kumar Singh
      Pages 91-107
    6. Association Between Ageing and REM Sleep Loss: Noradrenaline Acting as a Mediator

      • Rachna Mehta, Awanish Kumar, Birendra Nath Mallick
      Pages 109-126
    7. Aging: Influence on Duchenne Muscular Dystrophy (DMD) and Becker Muscular Dystrophy (BMD)

      • Niraj Kumar Srivastava, Ramakant Yadav, Deepak Sharma
      Pages 149-176
    8. Mitophagy, Diseases, and Aging

      • Sujit K. Bhutia, Prajna P. Naik, Debasna P. Panigrahi, Chandra S. Bhol, Kewal K. Mahapatra
      Pages 177-191
    9. Genetics, Ageing and Human Health

      • Parvez Khan, Aarfa Queen, Md. Imtaiyaz Hassan, Sher Ali
      Pages 193-209
    10. Genetic Syndromes and Aging

      • Kailash Chandra Mangalhara, R. N. K. Bamezai
      Pages 211-239
    11. Sex Steroids, Cognate Receptors, and Aging

      • Gargi Bagchi, Amit K. Dash, Sanjay Kumar, Shoulei Jiang, Soon C. Ahn, Bandana Chatterjee et al.
      Pages 265-296
    12. Immunosenescence, Inflammaging, and Their Implications for Cancer and Anemia

      • Sandeep Paudel, Priyanka Sharma, Niti Puri
      Pages 297-319
    13. Bone Marrow Stem Cells, Aging, and Age-Related Diseases

      • Naseem Ahamad, Pramod C. Rath
      Pages 321-352
  3. Interventions for Healthy Aging

    1. Front Matter

      Pages 353-353
    2. Infantile Radiation and Aging Stresses: Effects of Calorie and Dietary Restrictions

      • Yi Shang, Keiko Odera, Shizuko Kakinuma, Yoshiya Shimada, Ryoya Takahashi
      Pages 355-369

About this book

This book examines the basic cellular and molecular mechanisms associated with aging. It comprehensively describes the genetic, epigenetic, biochemical and metabolic regulation of aging, as well as some important age-related diseases. Divided into two major sections, it takes readers through the various aspects of aging in a story-like manner and suggests various interventions for healthy aging, such as dietary restriction, regular exercise, nutrition and maintaining a balanced and a non-stressful lifestyle. It describes the implications of aging on the nervous system, metabolism, immunity and stem cells as well as care for the elderly. The book is an ideal companion for both new and established researchers in the field and is also useful for educators, clinicians and policy makers.

Editors and Affiliations

  • School of Life Sciences, Jawaharlal Nehru University, New Delhi, India

    Pramod C. Rath

About the editor

Pramod C. Rath is a Professor of Molecular Biology at the School of Life Sciences, Jawaharlal Nehru University, New Delhi. He received his Ph. D. in Zoology (Biochemistry) in 1988 from the Banaras Hindu University, Varanasi on the topic ‘gene expression during aging’ under the supervision of Prof. M. S. Kanungo, who started research on ‘biology of aging’ in India. He completed his post-doctoral research at the Institute for Molecular Biology I, University of Zurich, Switzerland with Prof. Charles Weissmann, a well-known molecular biologist.

He has 27 years of teaching and research experience, having mentored 18 Ph. D. and 4 M. Phil. students. He has published his research in respected international journals, such as Ageing Research Reviews, Molecular Neurobiology, Journal of Molecular Neuroscience, International Journal of Developmental Neuroscience, RNA Biology, PLoS ONE, International Journal of Biological Macromolecules, Molecular Biology Reports, Journal of Biosciences, Biochemical Biophysical Research Communications, Biochimica Biophysica Acta, FEBS Letters, Journal of Clinical Immunology etc. He has published a Springer book, titled 'Topics in Biomedical Gerontology'.

He teaches molecular biology, molecular genetics & genetic engineering and cell signaling to master’s and Ph.D. students. Research in his laboratory is focused on cytokines; transcription factors; cell signaling and diseases; genomic biology of repetitive DNA and noncoding RNA; bone marrow stem cells and molecular aging in mammals. He has received numerous awards and fellowships and has been the Vice-President of the Association of Gerontology (India), Acting Dean at the School of Life Sciences. He is a member of several national academic and scientific committees.

Bibliographic Information

Buy it now

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access