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Integrative Structural Biology with Hybrid Methods

  • Book
  • © 2018

Overview

Editors:
  1. Haruki Nakamura

    1. Institute for Protein Research, Osaka University, Suita, Japan

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  2. Gerard Kleywegt

    1. European Bioinformatics Institute, Cambridgeshire, UK

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  3. Stephen K. Burley

    1. Rutgers, The State University of New Jersey, Piscataway, USA

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  4. John L. Markley

    1. Biochemistry Department, University of Wisconsin-Madison, Madison, USA

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  • Presents impact of the integrative structural biology
  • Provides Future perspective of the hybrid methods and their applications
  • Covers detailed description of experimental and computational methods in the hybrid methods

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1105)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-vi
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  3. New Experimental Tools Enabling Hybrid Methods

    1. Front Matter

      Pages 23-23
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    2. Complementary Use of Electron Cryomicroscopy and X-Ray Crystallography: Structural Studies of Actin and Actomyosin Filaments

      • Takashi Fujii, Keiichi Namba
      Pages 25-42

    3. Current Solution NMR Techniques for Structure-Function Studies of Proteins and RNA Molecules

      • John L. Markley
      Pages 43-58

    4. The PA Tag: A Versatile Peptide Tagging System in the Era of Integrative Structural Biology

      • Zuben P. Brown, Junichi Takagi
      Pages 59-76

    5. Small Angle Scattering and Structural Biology: Data Quality and Model Validation

      • Jill Trewhella
      Pages 77-100

    6. Structural Investigation of Proteins and Protein Complexes by Chemical Cross-Linking/Mass Spectrometry

      • Christine Piotrowski, Andrea Sinz
      Pages 101-121

    7. Prediction of Structures and Interactions from Genome Information

      • Sanzo Miyazawa
      Pages 123-152

    8. A Hybrid Approach for Protein Structure Determination Combining Sparse NMR with Evolutionary Coupling Sequence Data

      • Yuanpeng Janet Huang, Kelly P. Brock, Chris Sander, Debora S. Marks, Gaetano T. Montelione
      Pages 153-169

    9. Harnessing the Combined Power of SAXS and NMR

      • A. M. Gronenborn
      Pages 171-180

    10. 2DHybrid Analysis

      • Atsushi Matsumoto, Kenji Iwasaki
      Pages 181-196

  5. Data Validation and Archives for Hybrid Methods

    1. Front Matter

      Pages 259-259
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Keywords

About this book

This book presents a new emerging concept of "Integrative Structural Biology". It covers current trends of the molecular and cellular structural biology, providing new methods to observe, validate, and keep the structural models of the large cellular machines with recent scientific results. Structures of very large macromolecular machines in cells are being determined by combining observations from complementary experimental methods. Thus, this volume presents the each methods such as X-ray crystallography, NMR spectroscopy, 3DEM, small-angle scattering (SAS), FRET, crosslinking, and enables the readers to understand the hybrid methods. This book discusses how those integrative models should be represented, validated and archived. A unique highlight of this book is discussion of the data validation and archive, which are big problems in this filed along with the progress of this field. The researchers in biology will be interested inthis book as a guide book for learning the current structure biology, but also those in structure biology may use this book as a comprehensive reference to cover broad topics.

Editors and Affiliations

  • Institute for Protein Research, Osaka University, Suita, Japan

    Haruki Nakamura

  • European Bioinformatics Institute, Cambridgeshire, UK

    Gerard Kleywegt

  • Rutgers, The State University of New Jersey, Piscataway, USA

    Stephen K. Burley

  • Biochemistry Department, University of Wisconsin-Madison, Madison, USA

    John L. Markley

About the editors

Haruki Nakamura

Osaka University, Institute for Protein Research, Japan

Gerard J. Kleywegt

European Bioinformat Inst, Prot Data Bank Europe, England

Stephen K. Burley

Rutgers State University, Center for Integrative Proteomics Research, USA

John L. Markley 

University of Wisconsin, Biochemistry Department, Natl Magnet Resonance Facil Madison, USA

Bibliographic Information

  • Book Title: Integrative Structural Biology with Hybrid Methods

  • Editors: Haruki Nakamura, Gerard Kleywegt, Stephen K. Burley, John L. Markley

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-981-13-2200-6

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2018

  • Hardcover ISBN: 978-981-13-2199-3Published: 25 January 2019

  • eBook ISBN: 978-981-13-2200-6Published: 08 January 2019

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: VI, 272

  • Number of Illustrations: 17 b/w illustrations, 44 illustrations in colour

  • Topics: Protein Structure, Cell Biology

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