Overview
- Presents the latest knowledge on a range of topics relating to the synthesis of therapeutic oligonucleotides
- Aims to provide novel insights and inspire fresh ideas in nucleic acid chemistry
- Meets the needs of both established researchers and students new to the field
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Table of contents (16 chapters)
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Synthesis of Natural Oligonucleotides
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Synthesis and Properties of Artificial Oligonucleotides
Keywords
About this book
This book presents the latest knowledge on a broad range of topics relating to the synthesis of natural and artificial oligonucleotides with therapeutic potential. Nucleic acid-based therapeutics are attracting much attention, and numerous therapeutic oligonucleotides, such as antisense oligonucleotides, siRNAs, splice-switching oligonucleotides, and nucleic acid aptamers, are being evaluated in clinical trials for the treatment of a variety of diseases. Synthesis of Therapeutic Oligonucleotides covers a broad range of topics in the field that are of high relevance to researchers, including the synthesis of natural and chemically modified oligonucleotides, the development of novel nucleic acid analogs, industrial scale synthesis and purification of oligonucleotides, and important aspects of chemistry, manufacturing, and controls (CMC). The aim is to provide new insights and inspire fresh ideas in nucleic acid chemistry that may ultimately lead to novel concepts and techniques and the discovery of more effective nucleic acid drugs. The book will be of high value for both established researchers in the field and students intending to specialize in nucleic acid chemistry research.
Editors and Affiliations
About the editors
Satoshi Obika, Osaka University, Japan
Mitsuo Sekine, Tokyo Institute of Technology, Japan
Bibliographic Information
Book Title: Synthesis of Therapeutic Oligonucleotides
Editors: Satoshi Obika, Mitsuo Sekine
DOI: https://doi.org/10.1007/978-981-13-1912-9
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Singapore Pte Ltd. 2018
Hardcover ISBN: 978-981-13-1911-2Published: 19 December 2018
eBook ISBN: 978-981-13-1912-9Published: 08 December 2018
Edition Number: 1
Number of Pages: VIII, 284
Number of Illustrations: 173 b/w illustrations, 35 illustrations in colour
Topics: Pharmaceutical Sciences/Technology, Medicinal Chemistry, Molecular Medicine