Overview
This book highlights the different tyrosine kinases that are involved in gastrointestinal cancers
It describes the roles of tyrosine kinases in tumor growth and tumor cell metastasis including migration, invasion, and angiogenesis
This book also elucidates the rational targets for gastrointestinal cancers therapy
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Table of contents (16 chapters)
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Front Matter
Keywords
About this book
The aim of this book is to provide comprehensive overview of the role of different tyrosine kinases in the progression and metastasis of various cancers of the gastrointestinal tract such as esophagus, liver, pancreas, stomach, and colorectal. Activation of various signaling pathways and tyrosine kinases are responsible for resistance to chemo and radiotherapy in these gastrointestinal malignancies. Targeting these tyrosine kinases, which regulate the activities of survival pathways in growth, and metastasis is a rational strategy in gastrointestinal cancer therapy.
Each chapter embedded in this book covers information pertaining to a specific tyrosine kinase and its impact on various malignancies, which is not only significant for basic and clinical research investigations but will also be valued by students at advanced undergraduate to postgraduate levels.
Editors and Affiliations
About the editor
Dr. Nagaraju GP is a faculty member in the Department of Hematology and Medical Oncology at Emory University School of Medicine. He obtained his MSc and his Ph.D., both in biotechnology, from Sri Venkateswara University, Tirupati, Andhra Pradesh, India. His research focuses on translational projects related to gastrointestinal malignancies. He has published over 65 research articles in highly reputed international journals and has presented more than 50 abstracts at various national and international conferences. He has also served as an editorial board member of several internationally recognized academic journals. He is an associate member of the Discovery and Developmental Therapeutics research program at Winship Cancer Institute. He has received several prestigious international awards and holds memberships with the Association of Scientists of Indian Origin in America (ASIOA), the Society for Integrative and Comparative Biology (SICB), the Science Advisory Board, The RNA Society, and the American Association of Cancer Research (AACR).
Bibliographic Information
Book Title: Role of Tyrosine Kinases in Gastrointestinal Malignancies
Editors: Ganji Purnachandra Nagaraju
DOI: https://doi.org/10.1007/978-981-13-1486-5
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Singapore Pte Ltd. 2018
Hardcover ISBN: 978-981-13-1485-8Published: 11 October 2018
Softcover ISBN: 978-981-13-4640-8Published: 29 December 2018
eBook ISBN: 978-981-13-1486-5Published: 27 September 2018
Edition Number: 1
Number of Pages: XV, 241
Number of Illustrations: 7 b/w illustrations, 21 illustrations in colour
Topics: Cancer Research, Human Physiology, Cell Biology, Receptors, Gene Expression, Oncology