Functional Dyspepsia

1. Front Matter

   Pages i-viii

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2. Etiology

   1. Front Matter

      Pages 1-1

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   2. Definition and Prevalence

      • Tadayuki Oshima, Hiroto Miwa

      Pages 3-14

   3. Genetic Factor

      • Tomiyasu Arisawa

      Pages 15-23

   4. Environmental Factors

      • Hiroshi Takeda

      Pages 25-36

3. Pathophysiology

   1. Front Matter

      Pages 37-37

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   2. Neuro-gastroenterology: Central and Autonomic Nervous System

      • Kazunari Tominaga, Yoshiko Fujikawa

      Pages 39-49

   3. Neuro-gastroenterology: Enteric Nervous System

      • Yoshiko Fujikawa, Kazunari Tominaga

      Pages 51-58

   4. Neuro-gastroenterology: Esophagogastric Function (Motility)

      • Takeo Odaka

      Pages 59-67

   5. Neuro-gastroenterology: Gastroduodenal Function (Motility) and Ultrasonographic Assessment

      • Hiroaki Kusunoki, Ken Haruma, Noriaki Manabe, Tomoari Kamada, Jiro Hata

      Pages 69-90

   6. Ghrelin and Functional Dyspepsia

      • Koji Yakabi, Naomi Yamaguchi, Eriko Hosomi, Toru Aoyama, Kazuhito Kani, Naoya Miyagi

      Pages 91-103

   7. Psycho-gastroenterology

      • Tomotaka Shoji, Yuka Endo, Shin Fukudo

      Pages 105-115

   8. Visceral Hypersensitivity Through Transient Receptor Potential Vanilloid 1 Channels (TRPV1) in Functional Dyspepsia

      • Syunji Horie, Kenjiro Matsumoto, Kimihito Tashima

      Pages 117-126

4. Treatment

   1. Front Matter

      Pages 127-127

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   2. Efficacy of Acid Suppression Therapy

      • Kouichi Sakurai, Hiroko Suda

      Pages 129-138

   3. Prokinetics

      • Toshihisa Takeuchi, Satoshi Harada, Kazunari Tominaga, Kazuhide Higuchi

      Pages 139-145

   4. Herbal Medicine

      • Yasuyuki Shimoyama, Hiroko Hosaka, Shiko Kuribayashi, Osamu Kawamura, Motoyasu Kusano

      Pages 147-152

5. Recent Special Topics: Future Treatment Possibility

   1. Front Matter

      Pages 153-153

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   2. Gut Dysbiosis and Its Treatment in Patients with Functional Dyspepsia

      • Yuji Naito, Akifumi Fukui, Saori Kashiwagi, Tomohisa Takagi

      Pages 155-166

   3. Visceral Hypersensitivity in Functional Dyspepsia (FD): Therapeutic Approaches to FD Based on Suppression of Visceral Hypersensitivity

      • Yasuhito Uezono, Kanako Miyano

      Pages 167-177

The research and outcomes presented in this book gather evidence concerning both the pathogenesis and treatment of functional dyspepsia. It provides the latest information on this common non-organic disease, indicating its characteristic pathogenesis based on the brain-gut interaction and micro-environment and evidence gleaned from clinical treatment. Since the pathogenesis is associated with psychology, neurology, endocrinology and bacteriology in addition to gastroenterological physiology, it is often intractable and finding a suitable treatment rationale is challenging. Furthermore, the pathogenesis varies around the world and the efficacy of treatment using standard drugs varies among different populations worldwide; accordingly, this book highlights evidence gained in clinical trials in Japan.


Functional Dyspepsia is a milestone produced by respected experts. Addressing unique topics and new findings of treatment including challenging and/or future rationales, it offers an invaluable resource for general clinicians, gastroenterologists, and basic researchers alike. 

• FD
• Brain-Gut Interaction
• Motility
• Inflammation
• Acid
• Prokinetics
• Rome IV Criteria

“This is an outstanding monograph on functional gastrointestinal disorders, their genetics, causes, and treatments, which also outlines future research and treatments very well.” (Vincent F Carr, Doody's Book Reviews, January, 18, 2019)

• Premier Developmental Research of Medicine, Osaka Medical College, Takatsuki, Japan

  Kazunari Tominaga

• Department of General Medicine, Kawasaki Medical School, Kurashiki, Japan

  Hiroaki Kusunoki

Kazunari Tominaga, Osaka Medical College, Second Department of Internal Medicine, Takatsuki, Japan
Hiroaki Kusunoki, Kawasaki Medical School, Department of General Medicine, Kurashiki, Japan

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