Overview
- Offers an in-depth and comprehensive review on current understanding of regulatory ncRNAs in complex diseases from the view of bioinformatics
- Conveys state-of-the-art bioinformatics tools and methods for ncRNAs from computational detection, functional prediction, to their roles in disease
- Provides important information on current progress in this fast-moving field of bioinformatics for regulatory ncRNAs
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1094)
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Table of contents (12 chapters)
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Front Matter
Keywords
About this book
This book offers an in-depth and comprehensive review on current understanding of regulatory ncRNAs in complex diseases from a view of bioinformatics. It conveys state-of-the-art bioinformatics tools and methods for ncRNAs from computational detection, functional prediction, to their roles in diseases. Computational methods used to investigate uncharacterised ncRNAs in diseases are mainly summarized in seven aspects: DNA variation of ncRNAs in diseases, prioritization of disease-related ncRNAs, dysregulation epigenetic factors that regulate ncRNA misexpression (DNA methylation and histone-modification), complex crosstalk across ncRNAs, ncRNAs acted as competing regulators to mediate the expression of protein-coding genes, non-coding RNAs mediated risk pathways,and their contributions to drug target predictions. The generally used data resources of ncRNAs are also listed in the end. This book provides important information on the current progress in the fast-moving fields of bioinformatics for regulatory ncRNAs. It provides a timely and useful reference for computational biologists, specifically with RNA interests, and other related areas.
Prof. Xia Li is a Professor and the Dean of College of Bioinformatics Science and Technology, Harbin Medical University, China. Dr. Yun Xiao, Dr. Juan Xu, Dr. Shangwei Ning and Dr. Yunpeng Zhang are from College of Bioinformatics Science and Technology, Harbin Medical University, China.
Editors and Affiliations
About the editors
Bibliographic Information
Book Title: Non-coding RNAs in Complex Diseases
Book Subtitle: A Bioinformatics Perspective
Editors: Xia Li, Juan Xu, Yun Xiao, Shangwei Ning, Yunpeng Zhang
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-981-13-0719-5
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Singapore Pte Ltd. 2018
Hardcover ISBN: 978-981-13-0718-8Published: 19 September 2018
Softcover ISBN: 978-981-13-4486-2Published: 19 January 2019
eBook ISBN: 978-981-13-0719-5Published: 06 September 2018
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: X, 126
Number of Illustrations: 5 b/w illustrations, 37 illustrations in colour
Topics: Bioinformatics, Human Genetics