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  • © 2019

Advanced Optical Methods for Brain Imaging

  • Compiles topics starting from the basics of neuroscience to the most recent advances in structural and functional brain imaging technologies
  • Presents focused and comprehensive description of the physical principles, instrumentation, and the most recent brain imaging applications using optical methods
  • Addresses the development of novel techniques like adaptive optics, click chemistry reactions, artificial neural networks, and the CLARITY method in the field of brain imaging

Part of the book series: Progress in Optical Science and Photonics (POSP, volume 5)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xx
  2. Overview

    1. Front Matter

      Pages 1-1
    2. Multiscale and Multimodal Imaging for Connectomics

      • Ankur Gogoi, Gerd Keiser, Fu-Jen Kao, Ann-Shyn Chiang
      Pages 3-45
  3. Advanced Optical Microscopy Methods

    1. Front Matter

      Pages 47-47
    2. Optical Coherence Tomography for Brain Imaging

      • Bernhard Baumann
      Pages 49-68
    3. Light-Sheet Microscopy for Whole-Brain Imaging

      • Monika Pawłowska, Marzena Stefaniuk, Diana Legutko, Leszek Kaczmarek
      Pages 69-81
    4. Recording Ca++ Transients in Neurons by TCSPC FLIM

      • Wolfgang Becker, Samuel Frere, Inna Slutsky
      Pages 103-110
  4. Multiphoton Microscopy

    1. Front Matter

      Pages 111-111
    2. Patterned Two-Photon Illumination for High-Speed Functional Imaging of Brain Networks In Vivo

      • Serena Bovetti, Claudio Moretti, Tommaso Fellin
      Pages 123-141
    3. Holographic Functional Calcium Imaging of Neuronal Circuit Activity

      • Michael Castanares, Greg J. Stuart, Vincent Daria
      Pages 143-165
    4. Advanced Miniature Microscopy for Brain Imaging

      • Weijian Zong, Liangyi Chen
      Pages 167-187
  5. Super-Resolution Microscopy

    1. Front Matter

      Pages 219-219
    2. Super-Resolution STED and STORM/PALM Microscopy for Brain Imaging

      • Boris Egger, Simon G. Sprecher
      Pages 245-258
    3. Expansion Microscopy for Brain Imaging

      • Jae-Byum Chang
      Pages 259-273
  6. Supporting Technologies in Brain Imaging

    1. Front Matter

      Pages 275-275
    2. Adaptive Optics in Multiphoton Microscopy

      • Juan M. Bueno
      Pages 277-294

About this book

This book highlights the rapidly developing field of advanced optical methods for structural and functional brain imaging. As is known, the brain is the most poorly understood organ of a living body. It is indeed the most complex structure in the known universe and, thus, mapping of the brain has become one of the most exciting frontlines of contemporary research. Starting from the fundamentals of the brain, neurons and synapses, this book presents a streamlined and focused coverage of the core principles, theoretical and experimental approaches, and state-of-the-art applications of most of the currently used imaging methods in brain research. It presents contributions from international leaders on different photonics-based brain imaging modalities and techniques. Included are comprehensive descriptions of many of the technology driven spectacular advances made over the past few years that have allowed novel insights of the structural and functional details of neurons.

The bookis targeted at researchers, engineers and scientists who are working in the field of brain imaging, neuroscience and connectomics. Although this book is not intended to serve as a textbook, it will appeal to undergraduate students engaged in the specialization of brain imaging.

Editors and Affiliations

  • Institute of Biophotonics, National Yang-Ming University, Taipei, Taiwan

    Fu-Jen Kao, Ankur Gogoi

  • Department of Electrical and Computer Engineering, Boston University, Boston, USA

    Gerd Keiser

About the editors

Fu-Jen Kao is a Professor at Institute of Biophotonics, National Yang-Ming University, Taiwan. At present, he is the Vice President of the Association of Asia Pacific Physical Societies. He was also the former Director, Institute of Biophotonics, National Yang-Ming University and former President of the Physics Society of ROC, Taiwan. In addition, he has served as the Chief of Research and Planning, Office of Research Affair, Professor of Institute of Electro-Optical Engineering and Professor of the Department of Physics at National Sun Yat-sen University. He is a fellow of Royal Microscopy Society and SPIE, associate editor of IEEE TBME and reviewer of a number of international research journals. The research laboratory led by him has successfully developed many advanced techniques based on multiphoton microscopy with a wide variety of imaging modalities, including two-photon, OBIC, SHG, THG, CARS, stimulated emission, FLIM/FRET, etc. In addition to championing these developments, hehas transferred many of the above techniques to a large number of interested research groups both domestically and internationally. He has authored over 90 SCI Journal Papers, edited two books, and presented his research at over 100 international conferences. He received his Bachelor of Science (BA) in Physics from the National Taiwan University (June, 1983), Master of Science (MA) in Physics from Cornell University (August, 1988) and Doctor of Philosophy (PhD) in Physics from Cornell University (August, 1993).

Gerd Keiser is Research Professor at Boston University and Professor and consultant at PhotonicsComm Solutions, a firm specializing in education and consulting for the optical communications and biophotonics industries. Previously he was involved with telecom technologies at Honeywell, GTE, and General Dynamics. His technical achievements at GTE earned him the prestigious Leslie Warner Award. In addition, he has served as Adjunct Professor of Electrical Engineering at Northeastern University, Boston University, and Tufts University, and was an industrial advisor to the Wentworth Institute of Technology. Formerly he was a chair professor in the Electronics Engineering Department at the National Taiwan University of Science and Technology. He also was a visiting researcher at the Agency for Science, Technology, and Research (A*STAR) in Singapore and at the University of Melbourne, Australia. He is a life fellow of the IEEE, a fellow of OSA and SPIE, an associate editor and reviewer of several technical journals, and the author of five books. He received his B.A. and M.S. degrees in Mathematics and Physics from the University of Wisconsin and a Ph.D. in Physics from Northeastern University. His professional experience and research interests are in the general areas of optical networking and biophotonics.

Ankur Gogoi is an Assistant Professor in the Department of Physics at Jagannath Barooah College, Assam, India and a post doctoral Research Associate at the Institute of Biophotonics, National Yang Ming University, Taiwan. Formerly, he also served as an Assistant  Professor in Physics in The Assam Kaziranga University, Assam, India and Girijananda Chowdhury Institute of Management and Technology – Tezpur, Assam, India. He is a reviewer of several international journals, author of more than a dozen international research publications, editor of one book and member of SPIE, OSA and the Optical Society of India (OSI). During the last 10 years he has been actively involved in optoelectronics, photonics and nanotechnology research, especially in the design and fabrication of laser based light scattering instruments for the characterization of small particulate matter. He completed B.Sc. in Physics from Dibrugarh University, India in 2004 and received M.Sc. and Ph.D. from Tezpur University, India in 2006 and 2012, respectively.

Bibliographic Information

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access