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Dengue and Zika: Control and Antiviral Treatment Strategies

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  • © 2018

Overview

Editors:
  1. Rolf Hilgenfeld

    1. Institute of Biochemistry, University of Lübeck, Lübeck, Germany

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  2. Subhash G. Vasudevan

    1. Emerging Infectious Diseases Program, Duke-NUS Medical School Singapore, Singapore, Singapore

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Provides broad coverage of dengue and zika countermeasures
  • Written by leading experts in the field
  • Gives transcripts of lively discussions at the end of each presentation – “the salt in the soup”
  • Shows industry perspective on dengue and zika antiviral discovery and development

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1062)

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Table of contents (25 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Arboviruses: A Family on the Move

    • Paul R. Young
    Pages 1-10

  3. Historical Perspective of Arboviruses in Mozambique and Its Implication for Current and Future Epidemics

    • Eduardo Samo Gudo, Kerstin Falk, Julie Cliff
    Pages 11-18

  4. Reliable Serological Testing for the Diagnosis of Emerging Infectious Diseases

    • Claudia Ohst, Sandra Saschenbrecker, Konstanze Stiba, Katja Steinhagen, Christian Probst, Christiane Radzimski et al.
    Pages 19-43

  5. Flaviviral RNA Structures and Their Role in Replication and Immunity

    • Katell Bidet, Mariano A. Garcia-Blanco
    Pages 45-62

  6. The Molecular Specificity of the Human Antibody Response to Dengue Virus Infections

    • Emily N. Gallichotte, Ralph S. Baric, Aravinda M. de Silva
    Pages 63-76

  7. Structures of Zika Virus E & NS1: Relations with Virus Infection and Host Immune Responses

    • Yi Shi, Lianpan Dai, Hao Song, George F. Gao
    Pages 77-87

  8. Plugging the Leak in Dengue Shock

    • Daniel Watterson, Naphak Modhiran, David A. Muller, Katryn J. Stacey, Paul R. Young
    Pages 89-106

  9. Viral Entry and NS1 as Potential Antiviral Drug Targets

    • Aravinda M. de Silva, Félix A. Rey, Paul R. Young, Rolf Hilgenfeld, Subhash G. Vasudevan
    Pages 107-113

  10. The Dengue Virus Replication Complex: From RNA Replication to Protein-Protein Interactions to Evasion of Innate Immunity

    • Julien Lescar, Sherryl Soh, Le Tian Lee, Subhash G. Vasudevan, Congbao Kang, Siew Pheng Lim
    Pages 115-129

  11. The Structure of the Zika Virus Protease, NS2B/NS3pro

    • Rolf Hilgenfeld, Jian Lei, Linlin Zhang
    Pages 131-145

  12. The Transactions of NS3 and NS5 in Flaviviral RNA Replication

    • Moon Y. F. Tay, Subhash G. Vasudevan
    Pages 147-163

  13. Establishment and Application of Flavivirus Replicons

    • Beate M. Kümmerer
    Pages 165-173

  14. Strategies Towards Protease Inhibitors for Emerging Flaviviruses

    • Christoph Nitsche
    Pages 175-186

  15. Discovery of Potent Non-nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from Fragment Screening and Structure-Guided Design

    • Siew Pheng Lim, Christian G. Noble, Shahul Nilar, Pei-Yong Shi, Fumiaki Yokokawa
    Pages 187-198

  16. Nucleocytoplasmic Trafficking of Dengue Non-structural Protein 5 as a Target for Antivirals

    • David A. Jans, Alexander J. Martin
    Pages 199-213

  17. Animal Models for Dengue and Zika Vaccine Development

    • Eduardo Alves dos Santos, Katja Fink
    Pages 215-239

  18. Understanding the Human T Cell Response to Dengue Virus

    • Laura Rivino
    Pages 241-250

  19. Regulation and Function of NK and T Cells During Dengue Virus Infection and Vaccination

    • Anuja Mathew
    Pages 251-264

  20. Structural Insights into the Broad-Spectrum Antiviral Target Endoplasmic Reticulum Alpha-Glucosidase II

    • Alessandro T. Caputo, Dominic S. Alonzi, John L. Kiappes, Weston B. Struwe, Alice Cross, Souradeep Basu et al.
    Pages 265-276
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Keywords

About this book

This contributed volume contains 25 chapters from leading international scientists working on dengue and Zika viruses, who came together in Praia do Tofo in Mozambique to discuss the latest developments in the fields of epidemiology, pathogenesis, structural virology, immunology, antiviral drug discovery and development, vaccine efficacy, and mosquito control programs. The meeting venue offered an opportunity to discuss current research on these flaviviruses in an idyllic setting, and also to develop first-hand appreciation of the issues in infectious diseases facing developing countries and of the research gaps in Africa.

For readers, who should include basic and clinical researchers in the field and public health professionals, the chapters are organized to provide a comprehensive overview of the various topics in current dengue and Zika virus research.

A unique feature of the proceedings of this meeting is the inclusion of the discussions that took place following presentations. These have been transcribed and appended to the end of the relevant chapters, and they form the “salt in the soup” of this book.


Editors and Affiliations

  • Institute of Biochemistry, University of Lübeck, Lübeck, Germany

    Rolf Hilgenfeld

  • Emerging Infectious Diseases Program, Duke-NUS Medical School Singapore, Singapore, Singapore

    Subhash G. Vasudevan

Bibliographic Information

  • Book Title: Dengue and Zika: Control and Antiviral Treatment Strategies

  • Editors: Rolf Hilgenfeld, Subhash G. Vasudevan

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-981-10-8727-1

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2018

  • Hardcover ISBN: 978-981-10-8726-4Published: 14 June 2018

  • Softcover ISBN: 978-981-13-4225-7Published: 11 February 2019

  • eBook ISBN: 978-981-10-8727-1Published: 29 May 2018

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIII, 375

  • Number of Illustrations: 29 b/w illustrations, 70 illustrations in colour

  • Topics: Virology

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