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Synthetic Biology

Omics Tools and Their Applications

  • Book
  • © 2018

Overview

Editors:
  1. Shailza Singh

    1. Department of Pathogenesis and Cellular Response, National Centre for Cell Science, Computational and Systems Biology Lab, Pune, India

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  • Discusses the concepts of synthetic and systems biology in a comprehensive yet lucid manner

  • Presents the latest applications of synthetic biology in different areas of biology

  • Gives insights into methods to handle and use the massive Omics data

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-vii
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  2. Integrated Systems and Chemical Biology Approach for Targeted Therapies

    • Ritika Kabra, Bhavnita Soni, Anurag Kumar, Nutan Chauhan, Prajakta Ingale, Shailza Singh
    Pages 1-19

  3. Application of Bioengineering in Revamping Human Health

    • Shreya Ghosh, M. S. Kumar, Bhubaneswari Bal, A. P. Das
    Pages 21-37

  4. Integrative Omics for Interactomes

    • Debangana Chakravorty, Krishnendu Banerjee, Sudipto Saha
    Pages 39-49

  5. Studying Parasite Gene Function and Interaction Through Ribozymes and Riboswitches Design Mechanism

    • Harish Shukla, Timir Tripathi
    Pages 51-74

  6. Genome Microbiology for Synthetic Applications

    • Taj Mohammad, Md. Imtaiyaz Hassan
    Pages 75-86

  7. Medicinal Application of Synthetic Biology

    • Umesh Panwar, Poonam Singh, Sanjeev Kumar Singh
    Pages 87-94

  8. Computational Tools for Applying Multi-level Models to Synthetic Biology

    • Roberta Bardini, Gianfranco Politano, Alfredo Benso, Stefano Di Carlo
    Pages 95-112

  9. Computational Techniques for a Comprehensive Understanding of Different Genotype-Phenotype Factors in Biological Systems and Their Applications

    • Abhishek Subramanian, Ram Rup Sarkar
    Pages 113-139

  10. Alignment-Free Analyses of Nucleic Acid Sequences Using Graphical Representation (with Special Reference to Pandemic Bird Flu and Swine Flu)

    • Ashesh Nandy, Antara De, Proyasha Roy, Munna Dutta, Moumita Roy, Dwaipayan Sen et al.
    Pages 141-188

  11. Modern Approaches in Synthetic Biology: Genome Editing, Quorum Sensing, and Microbiome Engineering

    • Taj Mohammad, Md. Imtaiyaz Hassan
    Pages 189-205

  12. Synthetic Probes, Their Applications and Designing

    • Shafaque Zahra, Ajeet Singh, Shailesh Kumar
    Pages 207-226

  13. Omics-Based Nanomedicine

    • Chirasmita Nayak, Ishwar Chandra, Poonam Singh, Sanjeev Kumar Singh
    Pages 227-248

  14. Characterization of Plant Genetic Modifications Using Next-Generation Sequencing

    • Ana Pérez-González, Álvaro Eseverri, Elena Caro
    Pages 249-259
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Keywords

About this book

The book uses an integrated approach to predict the behavior of various biological interactions. It further discusses how synthetic biology gathers the information about various systems, in order to either devise an entirely new system, or, to modulate existing systems. The book also tackles the concept of modularity, where biological systems are visualized in terms of their parts.

The chapters discuss how the principles of engineering are being used in biomedical sciences, to design biological circuits that can harbor multiple inputs and generate multiple outputs; to create genetic networks and control gene activity, in order to generate a desired response. The book aims to help the readers develop an array of biological parts, and to use these parts to develop synthetic circuits that can be assembled like electronic circuits. The ultimate aim of the book will be to serve as an amalgamation of key ideas of how judiciously synthetic biology could be exploited in therapeutic device and delivery mechanism.


Editors and Affiliations

  • Department of Pathogenesis and Cellular Response, National Centre for Cell Science, Computational and Systems Biology Lab, Pune, India

    Shailza Singh

About the editor

Shailza Singh is working as Scientist D at National Centre for Cell Science, Pune. She works in the field of Computational and Systems Biology wherein she is trying to integrate the action of regulatory circuits, cross-talk between pathways and the non-linear kinetics of biochemical processes through mathematical models. The current thrust in her laboratory is to explore the possibility of network-based drug design and how rationalized therapies may benefit from Systems Biology. She has published a book with Springer, titled 'Systems Biology Application in Synthetic Biology'. She is the recipient of RGYI (DBT), DST-Young Scientist and INSA (Bilateral Exchange Programme). She is the reviewer of various international and national grants funded from government organizations.

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