Clinical Relevance of Genetic Factors in Pulmonary Diseases

1. Front Matter

   Pages i-ix

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2. Introduction

   1. Front Matter

      Pages 1-1

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   2. Clinical Development of Genomic Medicine in Pulmonary Diseases: Are Genetic Factors Enough to Determine the Phenotype and Inheritance of Pulmonary Diseases?

      • Mari Hikichi, Shuichiro Maruoka, Shu Hashimoto

      Pages 3-14

   3. Approaches to Understanding the Genetic Basis of Complex Diseases: Overview—What Is the Rationale for the Genome-Wide Approach to Understand Complex Diseases, Its Application and Limitations

      • Mayumi Tamari, Tomomitsu Hirota

      Pages 15-35

3. Genetic Disorders in Pulmonary Disease

   1. Front Matter

      Pages 37-37

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   2. Bronchial Asthma: Is Asthma Inherited?

      • Nobuyuki Hizawa

      Pages 39-56

   3. COPD: Hereditary (A1-AT) and Non-hereditary—What Are the Roles of Genetic Factors in the Pathogenesis of COPD?

      • Nobuyuki Horita

      Pages 57-75

   4. Smoking Behavior and Cessation (Nicotine Addiction): Are Genetic Factors Involved in Smoking Behavior?

      • Tetsuya Kubota, Akihito Yokoyama

      Pages 77-91

   5. Cystic Fibrosis, Primary Ciliary Dyskinesia, and Diffuse Panbronchiolitis: Hereditary and Non-hereditary—What Are the Roles of Genetic Factors in the Pathogenesis of These Diseases?

      • Masaharu Shinkai

      Pages 93-106

   6. Pulmonary Fibrosis: Hereditary and Non-hereditary—What Are the Role of Genetic Factors in the Pathogenesis of Pulmonary Fibrosis?

      • Takafumi Suda

      Pages 107-133

   7. Other Diffuse Lung Diseases: Diffuse Cystic Lung Diseases (LAM, TSC, BHD), Sarcoidosis, Pulmonary Alveolar Proteinosis, and Pulmonary Alveolar Microlithiasis—What Are the Roles of Genetic Factors in the Pathogenesis of These Diseases?

      • Haruhiko Furusawa, Masahiro Masuo, Yoshihisa Nukui, Yasunari Miyazaki, Naohiko Inase

      Pages 135-160

   8. Pulmonary Vascular Diseases: Pulmonary Hypertension and HHT—What Are the Roles of Genetic Factors in the Pathogenesis of Pulmonary Vascular Diseases?

      • Toshihiko Sugiura, Koichiro Tatsumi

      Pages 161-167

   9. Mycobacterial Infection: TB and NTM—What Are the Roles of Genetic Factors in the Pathogenesis of Mycobacterial Infection?

      • Kazuko Yamamoto, Hiroshi Mukae

      Pages 169-191

   10. Pulmonary Malignancies (1): Lung Cancer—What Are the Roles of Genetic Factors in Lung Cancer Pathogenesis?

       • Naozumi Hashimoto, Mitsuo Sato, Yoshinori Hasegawa

       Pages 193-206

   11. Pulmonary Malignancies (2): Mesothelioma—What Are the Roles of Genetic Factors in the Pathogenesis of Mesothelioma?

       • Takashi Nakano, Eisuke Shibata, Kozo Kuribayashi, Yoshie Yoshikawa, Masaki Ohmuraya

       Pages 207-224

   12. Genetic Factors in Sleep Disorders: What Are the Roles of Genetic Factors in the Pathogenesis of Sleep Disorders?

       • Kiminobu Tanizawa, Kazuo Chin

       Pages 225-254

   13. Pharmacokinetics, Pharmacodynamics, and Toxicities: What Should We Know About Genetic Factors that Affect the Pharmacotherapy of Pulmonary Diseases?

       • Takashi Sato

       Pages 255-271

4. Oncogenic Driver Mutation (Somatic Mutations) in Lung Cancer

   1. Front Matter

      Pages 273-273

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   2. EGFR: How Important Is EGFR Mutation Status in the Management of Lung Cancer?

      • Mizuki Haraguchi, Kazuhisa Takahashi

      Pages 275-293

   3. ALK and Others: How Important Are ALK and Other Mutations in the Management of Lung Cancer?

      • Hisatsugu Goto, Yasuhiko Nishioka

      Pages 295-315

This book describes the underlying genetic basis of common pulmonary diseases and discusses their pathogenesis and pathophysiology. These insights provide the basis for understanding different subtypes and phonotypes, and will promote better treatment strategies and individualized medicine. The book provides new and valuable information for the development of the areas of study, as well as practical guidelines for clinicians engaged in treating pulmonary diseases.

This volume of the Respiratory Disease Series – Diagnostic Tools and Disease Managements will broaden the understanding of beginning and experienced researchers and clinicians who treat pulmonary diseases. Moreover, residents and clinicians engaged in medical oncology will find it a valuable guide to support them in their day-to-day work.

• Smoking
• Bronchial Athma
• COPD
• Airway Disease
• Heriditary Disease
• Non-Heriditary Disease
• IPF
• Pulmonary Fibrosis
• Sleep Disorder
• Personal Genome Service

• Yokohama City University, Yokohama, Japan

  Takeshi Kaneko

Hiroyuki Nakamura, Department of Respiratory Medicine, 
Tokyo Medical University, Ibaraki Medical Center, 
Ibaraki, 
Japan

Kazutetsu Aoshiba, 
Department of Respiratory Medicine, 
Tokyo Medical University, Ibaraki Medical Center, 
Ibaraki, 
Japan


Takeshi Kaneko, 

Department of Pulmonology, 
Yokohama City University Graduate School of Medicine, 
Yokohama, 
Japan

Policies and ethics