Overview
- Focuses on the relationship between the regulation of signal transduction and disease mechanisms
- Highlights essential molecules and intracellular signaling pathways
- Help readers understand how the dysregulation of intracellular signals leads to diseases
Part of the book series: Current Human Cell Research and Applications (CHCRA)
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Table of contents (10 chapters)
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Front Matter
Keywords
About this book
This volume focuses on the relationship between the regulation of signal transduction and disease mechanisms, and discusses how the dysregulation of intracellular signals cause diseases, cell death, carcinogenesis, and other disorders.
Growth, survival, transformation, and metabolic activities at the cellular level are regulated by various intracellular signal transduction pathways. Sources that stimulate intracellular signals include intracellular stresses and signal regulators/modulators, as well as extracellular growth factors. Recent studies on signal transduction analysis using animal and human cell lines have revealed how the intracellular signals are regulated and why their dysregulation leads to pathological states such as tumorigenesis, metabolic diseases, cell death, and so on.
This book highlights several important key molecules and intracellular signaling pathways such as microRNA, the TGF-beta signaling pathway, the Wnt signaling pathway and MET signaling pathway as topical and highly relevant issues in human cell research related to signal transduction. In addition to assessing the pathogenic role of these signaling pathways, it focuses on the molecular design of small molecule regulators/inhibitors of said pathways, one of the most important approaches in this area.
This book offers a valuable guide, helping not only research scientists but also clinicians to understand how the dysregulation of intracellular signals leads to diseases.
Editors and Affiliations
About the editors
Nariyoshi Shinomiya
Department of Integrative Physiology and Bio‐Nano Medicine, National Defense Medical College, Tokorozawa, Japan
Hiroaki Kataoka
Department of Pathology, University of Miyazaki, Miyazaki, Japan
Qian Xie
Department of Biomedical Sciences, East Tennessee State University, Johnson City,
TN, USA
Bibliographic Information
Book Title: Regulation of Signal Transduction in Human Cell Research
Editors: Nariyoshi Shinomiya, Hiroaki Kataoka, Qian Xie
Series Title: Current Human Cell Research and Applications
DOI: https://doi.org/10.1007/978-981-10-7296-3
Publisher: Springer Singapore
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer Nature Singapore Pte Ltd. 2018
Hardcover ISBN: 978-981-10-7295-6Published: 01 March 2018
Softcover ISBN: 978-981-13-3934-9Published: 11 February 2019
eBook ISBN: 978-981-10-7296-3Published: 15 February 2018
Series ISSN: 2522-073X
Series E-ISSN: 2522-0748
Edition Number: 1
Number of Pages: VIII, 218
Number of Illustrations: 8 b/w illustrations, 41 illustrations in colour
Topics: Oncology, Medical Biochemistry, Cancer Research