Overview
- Presents a historical overview of eukaryotic DNA replication by one of the legendary scientists in the field
- Reviews comprehensive compilation of the newest information on DNA replication
- Approaches issues related to DNA replication from various points of view
- Emphasizes the latest results on mechanistic and structural aspects of DNA replication
- Features the most recent development on the genome-wide view of where and when DNA replication starts and stops, and how those profiles are correlated with other genomic signatures
- Provides a novel concept for the highly adaptive and plastic mode of eukaryotic DNA replication
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1042)
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Table of contents (23 chapters)
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Front Matter
Keywords
- Replication origins
- DNA replication initiation factors: DnaA, ORC, MCM
- Replication timing: TAD, LAD, and Rif1
- Chromatin regulation of DNA replication
- Structures of replication complexes: Cryoelectron microscopy
- Ubiquitination and SUMOylation of replication factors
- Replication/transcription collision
- G-quadruplex and RNA–DNA hybrids
- Replication fork factors
- Chromosomal fragile sites
- Clamp loaders
- Repetitive DNA elements
- Genome instability
- DNA polymerases
- FEN1
- cytogenetics
About this book
This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field. The following chapters include genome-wide studies of replication origins and initiation factor binding, as well as the timing of DNA replications, mechanisms of initiation, DNA chain elongation and termination of DNA replication, the structural basis of functions of protein complexes responsible for execution of DNA replication, cell cycle-dependent regulation of DNA replication, the nature of replication stress and cells’ strategy to deal with the stress, and finally how all these phenomena are interconnected to genome instability and development of various diseases. By reviewing the existing concepts ranging from the old principles to the newest ideas, the book gives readers an opportunity to learn how the classical replication principles are now being modified and new concepts are being generated to explain how genome DNA replication is achieved with such high adaptability and plasticity. With the development of new methods including cryoelectron microscopy analyses of huge protein complexes, single molecular analyses of initiation and elongation of DNA replication, and total reconstitution of eukaryotic DNA replication with purified factors, the field is enjoying one of its most exciting moments, and this highly timely book conveys that excitement to all interested readers.
Reviews
Editors and Affiliations
About the editors
Marco Foiani, IFOM, Instituto FIRC di Oncologia Molecolare, Milan, Italy
Bibliographic Information
Book Title: DNA Replication
Book Subtitle: From Old Principles to New Discoveries
Editors: Hisao Masai, Marco Foiani
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-981-10-6955-0
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Nature Singapore Pte Ltd. 2017
Hardcover ISBN: 978-981-10-6954-3Published: 31 January 2018
Softcover ISBN: 978-981-13-4972-0Published: 12 December 2018
eBook ISBN: 978-981-10-6955-0Published: 22 January 2018
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XII, 581
Number of Illustrations: 7 b/w illustrations, 87 illustrations in colour
Topics: Cell Biology, Cytogenetics, Biochemistry, general