Overview
- Introduces the basic information of mtDNA
- Summarize the latest development of mtDNA and disease
- Focus on mtDNA biology and the roles of mtDNA in disease
- Includes supplementary material: sn.pub/extras
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1038)
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Table of contents (15 chapters)
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Front Matter
Keywords
About this book
The book describes molecular principles and mechanisms by which mitochondrial DNA (mtDNA) can drive the occurrence of diseases and the latest understanding of mtDNA biology. The book explores roles of mtDNA mutation and genetic changes in cancer, with a special focus on lung cancer, and the significance of approach, application, and bioethics of mtDNA sequencing.  Authors made a great effort to overview roles of mtDNA signaling pathways, base excision repair, methylation, USP30-mediated regulation, mitochondrial ribosome, autophagy pathways, or ROS-dependent signaling in the pathogenesis, diagnosis, prevention and treatment of diseases. It also demonstrates the importance of basic mitochondrial genetics and the relationship between mutations and disease phenotypes and ageing. This book covers not only the basic information of mtDNA, the relationship of mtDNA and disease, but also mtDNA in stem cell and mitochondria and metabolism etc. The book is written for biological and clinicalstudents and researchers in the field of mtDNA–associated diseases.
Editors and Affiliations
About the editors
Dr. Hongzhi Sun is Professor and President of Jinzhou Hospital, Jinzhou Medical University, Jinzhou, Liaoning Province, China.
Dr. Xiangdong Wang is Distinguished Professor of Medicine, Director of Shanghai Institute of Clinical Bioinformatics, Executive Director of Clinical Science Institute of Fudan University Zhongshan Hospital, Deputy Director of Shanghai Respiratory Research Institute, Shanghai, China.
Bibliographic Information
Book Title: Mitochondrial DNA and Diseases
Editors: Hongzhi Sun, Xiangdong Wang
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-981-10-6674-0
Publisher: Springer Singapore
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2017
Hardcover ISBN: 978-981-10-6673-3Published: 08 December 2017
Softcover ISBN: 978-981-13-4929-4Published: 12 December 2018
eBook ISBN: 978-981-10-6674-0Published: 25 November 2017
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: VII, 230
Number of Illustrations: 27 b/w illustrations, 62 illustrations in colour
Topics: Cell Biology, Human Genetics