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DJ-1/PARK7 Protein

Parkinson’s Disease, Cancer and Oxidative Stress-Induced Diseases

  • Book
  • © 2017

Overview

Editors:
  1. Hiroyoshi Ariga

    1. Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan

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    You can also search for this editor in PubMed   Google Scholar

  2. Sanae M. M. Iguchi-Ariga

    1. Faculty of Agriculture, Hokkaido University, Sapporo, Japan

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Covers various oxidative stress-related diseases, including cancer, neurodegenerative diseases, and type 2 diabetes as well as male infertility
  • Broadens the understanding of the various uses of DJ-1 such as a biomarker for diagnosis of neurodegenerative diseases
  • Enriches understanding of DJ-1-binding compounds which are promising drugs for various oxidative stress-related diseases

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1037)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-viii
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  2. Introduction/Overview

    • Hiroyoshi Ariga, Sanae M. M. Iguchi-Ariga
    Pages 1-4

  3. Structural Biology of the DJ-1 Superfamily

    • Nathan Smith, Mark A. Wilson
    Pages 5-24

  4. Expression of DJ-1 in Neurodegenerative Disorders

    • Daria Antipova, Rina Bandopadhyay
    Pages 25-43

  5. Expression of DJ-1 in Cancer Cells: Its Correlation with Clinical Significance

    • Takahiko Kawate, Benio Tsuchiya, Keiichi Iwaya
    Pages 45-59

  6. Role of DJ-1 in Fertilization

    • An Chunna, Xiao-Ping Pu
    Pages 61-66

  7. The Multifaceted Roles of DJ-1 as an Antioxidant

    • Prahlad V. Raninga, Giovanna Di Trapani, Kathryn F. Tonissen
    Pages 67-87

  8. Transcriptional Regulation of DJ-1

    • Kazuko Takahashi-Niki, Takeshi Niki, Sanae M. M. Iguchi-Ariga, Hiroyoshi Ariga
    Pages 89-95

  9. Regulation of Signal Transduction by DJ-1

    • Stephanie E. Oh, M. Maral Mouradian
    Pages 97-131

  10. Protein Repair from Glycation by Glyoxals by the DJ-1 Family Maillard Deglycases

    • Mouadh Mihoub, Jad Abdallah, Gilbert Richarme
    Pages 133-147

  11. DJ-1 as a Biomarker of Parkinson’s Disease

    • Yoshiro Saito
    Pages 149-171

  12. The Role of the Antioxidant Protein DJ-1 in Type 2 Diabetes Mellitus

    • Daniel Eberhard, Eckhard Lammert
    Pages 173-186

  13. Therapeutic Activities of DJ-1 and Its Binding Compounds Against Neurodegenerative Diseases

    • Masatoshi Inden, Daijiro Yanagisawa, Masanori Hijioka, Hiroyoshi Ariga, Yoshihisa Kitamura
    Pages 187-202

  14. DJ-1 as a Therapeutic Target Against Cancer

    • Ji Cao, Xiaobing Chen, Meidan Ying, Qiaojun He, Bo Yang
    Pages 203-222
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Keywords

About this book

This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The DJ-1 gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinson’s disease (PD), park7. The DJ-1 gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of DJ-1, and explains the history and research development to understand the following chapters. Those chapters present the roles of DJ-1 in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader willdiscover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases. 

Editors and Affiliations

  • Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan

    Hiroyoshi Ariga

  • Faculty of Agriculture, Hokkaido University, Sapporo, Japan

    Sanae M. M. Iguchi-Ariga

About the editors

Hiroyoshi Ariga
Faculty of Pharmaceutical Sciences, Hokkaido University
Sapporo, Japan

Sanae M.M. Iguchi‐Ariga
Faculty of Agriculture, Hokkaido University
Sapporo,Japan

Bibliographic Information

  • Book Title: DJ-1/PARK7 Protein

  • Book Subtitle: Parkinson’s Disease, Cancer and Oxidative Stress-Induced Diseases

  • Editors: Hiroyoshi Ariga, Sanae M. M. Iguchi-Ariga

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-981-10-6583-5

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2017

  • Hardcover ISBN: 978-981-10-6582-8Published: 04 December 2017

  • Softcover ISBN: 978-981-13-4908-9Published: 12 December 2018

  • eBook ISBN: 978-981-10-6583-5Published: 16 November 2017

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: VIII, 222

  • Number of Illustrations: 32 b/w illustrations, 46 illustrations in colour

  • Topics: Cancer Research, Biochemistry, general, Neurosciences, Cell Biology

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