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Translational Research in Stroke

  • Book
  • © 2017

Overview

Editors:
  1. Paul A. Lapchak

    1. Department of Neurology & Neurosurgery, Cedars-Sinai Medical Center, Advanced Health Sciences Pavilion, Los Angeles, USA

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  2. Guo-Yuan Yang

    1. Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, China

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    You can also search for this editor in PubMed   Google Scholar

  • Summarizes the latest developments in translational research in stroke
  • Offers new therapeutics or rehabilitation and regenerative strategies
  • Provides a basis for effective translational research

Part of the book series: Translational Medicine Research (TRAMERE)

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Table of contents (26 chapters)

  1. Front Matter

    Pages i-vii
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  2. Stroke Epidemiology-Diagnosis

    1. Front Matter

      Pages 1-1
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    2. Stroke Therapy Development Successes: Research Guidelines and Embolic Stroke Models for Monotherapy and Adjuvant Therapy Development

      • Paul A. Lapchak
      Pages 3-27

    3. Recent Success with Endovascular Stroke Therapy

      • Konark Malhotra, David S. Liebeskind
      Pages 29-39

    4. Stroke Epidemiology

      • Chad M. Miller
      Pages 41-49

    5. Pathophysiology of Ischemic Stroke

      • Yongfang Li, Guo-Yuan Yang
      Pages 51-75

    6. Pathophysiology of Hemorrhagic Stroke

      • Zhongsong Shi
      Pages 77-96

    7. Brain Imaging for Stroke

      • Jin Cao, Min Lou
      Pages 97-126

    8. Unstable Carotid Artery Plaque Evaluation by Ultrasound

      • Noelia Rodriguez-Villatoro, David Rodriguez-Luna
      Pages 127-151

    9. Hypertension and Stroke

      • Jun Huang, Pingjin Gao
      Pages 153-167

    10. Diabetics and Stroke

      • Tingting He, Jieli Geng, Zhijun Zhang
      Pages 169-198

  3. Stroke Mechanisms

    1. Front Matter

      Pages 199-199
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    2. Mitochondrial Dysfunction in Ischemic Stroke

      • Qiang Li, Shane Gao
      Pages 201-221

    3. Molecular Mechanisms of Inflammation in Stroke

      • Parisa Tabeshmehr, Seyed Mojtaba Hosseini, Aliashghar Karimi, Seyyed Mohyeddin Ziaee
      Pages 223-236

    4. Immunology of Ischemic Stroke: Impact, Mechanisms, and Immunomodulatory Therapies

      • Jia Jia, Jian Cheng
      Pages 237-277

    5. Microglia Function in Stroke

      • Ran Xu, Adnan Ghori, Ulf C. Schneider, Peter Vajkoczy
      Pages 279-295

    6. Angiogenesis and Neurogenesis After Ischemic Stroke

      • Wanlu Li, Yongting Wang
      Pages 297-317

    7. MicroRNA Biomarkers for Stroke

      • Xuejing Zhang, Ping Sun, Ke-Jie Yin
      Pages 319-356

    8. Animal Models for Ischemic Stroke

      • Liping Wang, Chuan Qin, Guo-Yuan Yang
      Pages 357-379

  4. Stroke Therapy

    1. Front Matter

      Pages 381-381
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Keywords

About this book

This book mainly discusses the current status of stroke transnational research and allows the reader to understand the interplay of common comorbidities in the stroke population such as diabetes and hypertension, and provides insight into stroke targets to promote cell survival, angiogenesis, neurogenesis, and most importantly, functional recovery after stroke.
Throughout the world, stroke is still a leading cause of mortality and morbidity; each year approximately 15 million people worldwide suffer from stroke. Stroke is now the leading cause of death and disability in China. Large communities of stroke survivors are eagerly awaiting scientific advances in transnational stroke research that would offer neuroprotective therapeutics for acute stroke management, or rehabilitation and regenerative strategies utilizing novel stem cell-based approaches. While research is ongoing, the Editors have compiled this volume to help the further understanding of the pathophysiology of strokeand to review and identify future potential biomarkers. The book is written for students, researchers and physicians in neurosciences, neurology and neuroradiology.


Reviews

“This is a collection of research topics about various aspects of stroke, including an in-depth comparison of the trials that led to current practices, a breakdown of the pathophysiology of mechanisms involved in stroke, imaging, and future advances. … This is an excellent combination of academic principles and discussions of the relevant research studies. This book is ideal for an audience interested in neurology on both research and academic levels.” (Alison Caruana, Doody's Book Reviews, April, 2018)

Editors and Affiliations

  • Department of Neurology & Neurosurgery, Cedars-Sinai Medical Center, Advanced Health Sciences Pavilion, Los Angeles, USA

    Paul A. Lapchak

  • Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, China

    Guo-Yuan Yang

About the editors

Dr. Paul A. Lapchak is Director of Translational Research in the Departments of Neurology & Neurosurgery at Cedars-Sinai Medical Center in Los Angeles CA, USA; 
Dr. Guoyuan Yang is Professor at the School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China

Bibliographic Information

  • Book Title: Translational Research in Stroke

  • Editors: Paul A. Lapchak, Guo-Yuan Yang

  • Series Title: Translational Medicine Research

  • DOI: https://doi.org/10.1007/978-981-10-5804-2

  • Publisher: Springer Singapore

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd.and Shanghai Jiao Tong University Press 2017

  • Hardcover ISBN: 978-981-10-5803-5Published: 04 January 2018

  • Softcover ISBN: 978-981-13-5495-3Published: 12 December 2018

  • eBook ISBN: 978-981-10-5804-2Published: 20 December 2017

  • Series ISSN: 2451-991X

  • Series E-ISSN: 2451-9928

  • Edition Number: 1

  • Number of Pages: VII, 581

  • Number of Illustrations: 34 b/w illustrations, 31 illustrations in colour

  • Topics: Neurosciences, Neurology, Neuroradiology

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