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Hematological Disorders in Children

Pathogenesis and Treatment

  • Book
  • © 2017

Overview

Editors:
  1. Eiichi Ishii

    1. Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Japan

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  • Describe the pathogenesis and treatment of several representative hematological disorders in children

  • Special focus on the genetic and molecular aspects of childhood hematological disorders

  • Broadens readers’ understanding and will spark new discussions

  • Valuable resource for medical students, beginning investigators, and experienced scholars in the field of pediatric hematology and oncology

  • Includes supplementary material: sn.pub/extras

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-x
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  2. Hematopoiesis

    1. Front Matter

      Pages 1-1
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    2. Hematopoietic Stem Cells: The Basis of Normal and Malignant Hematopoiesis

      • Mariko Eguchi, Minenori Eguchi-Ishimae, Eiichi Ishii
      Pages 3-29

  3. White Blood Cell Disorders

    1. Front Matter

      Pages 31-31
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    2. Acute Lymphoblastic Leukemia

      • Daisuke Tomizawa, Nobutaka Kiyokawa
      Pages 33-60

    3. Acute Myeloid Leukemia

      • Souichi Adachi, Akitoshi Kinoshita, Daisuke Tomizawa, Takashi Taga, Hiroyuki Takahashi
      Pages 61-85

    4. Myelodysplastic Syndrome (MDS) and Juvenile Myelomonocytic Leukemia (JMML)

      • Daisuke Hasegawa, Atsushi Manabe
      Pages 87-108

    5. Neutropenia (In Infancy and Childhood)

      • Masao Kobayashi, Yoko Mizoguchi, Shuhei Karakawa, Satoshi Okada, Hiroshi Kawaguchi
      Pages 109-113

  4. Red Blood Cell Disorders

    1. Front Matter

      Pages 115-115
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    2. Childhood Aplastic Anemia

      • Hiroshi Yagasaki
      Pages 117-144

    3. Inherited Bone Marrow Failure Syndrome, TAM

      • Etsuro Ito, Kiminori Terui, Tsutomu Toki
      Pages 145-170

  5. Platelet and Coagulation Disorders

    1. Front Matter

      Pages 171-171
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    2. Immune and Inherited Thrombocytopenia in Children

      • Masue Imaizumi
      Pages 173-187

    3. Pathogenesis and Treatment of Hemophilia

      • Keiji Nogami, Midori Shima
      Pages 189-204

    4. Thrombotic Disorders

      • Shouichi Ohga, Masataka Ishimura
      Pages 205-221

  6. Histiocytic Disorders

    1. Front Matter

      Pages 223-223
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    2. Langerhans Cell Histiocytosis

      • Akira Morimoto
      Pages 225-246

    3. Primary Hemophagocytic Lymphohistiocytosis

      • Takahiro Yasumi, Hirofumi Shibata, Saeko Shimodera, Toshio Heike
      Pages 247-261

    4. Hemophagocytic Lymphohistiocytosis, Secondary

      • Ryu Yanagisawa, Yozo Nakazawa
      Pages 263-269
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Keywords

About this book

This book describes the pathogenesis and treatment of several representative hematological disorders in children, with a special focus on genetic and molecular aspects. Research on the pathogenesis of hematological disorders in children has made remarkable strides; especially molecular target therapy has shown outstanding effects in refractory and conventional therapies for childhood leukemia. The findings presented in this book will broaden readers’ understanding and hopefully spark new discussions leading to the development of new therapies including cell therapy and molecular target therapy, allowing clinicians to use more effective and less toxic approaches in the future.
Hematological Disorders in Children will appeal to a wide readership, from medical students and beginning investigators to experienced scholars in the field of pediatric hematology and oncology seeking to broaden their understanding and keep up with the latest developments. It will also be of interest to the parents of pediatric patients, and to co-medical staffs.


Reviews

“This unique treatise describes the pathogenesis and treatment modalities of childhood hematologic disorders that are both currently in use and that show future promise. ... The intended audience includes not only medical specialists who are involved in treating pediatric patients, but also medical students, research scientists, and even parents of afflicted children who can gain some perspective on the complexities of these disorders and the progress being made to treat them.” (Ravi Salgia, Doody's Book Reviews, April, 2018)



“A concise treatise which in 3 chapters divided into 3 parts summarizes present knowledge on hematological diseases in childhood. With illustrations, tables and many references. For pediatricians in practice and in training.” (Pediatric Endocrinology Reviews, Vol. 15 (2), December, 2017)

Editors and Affiliations

  • Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Japan

    Eiichi Ishii

About the editor

Editor: Dr Eiichi Ishii, Department of Pediatrics, Ehime University Graduate School of Medicine, Toon, Japan

Bibliographic Information

  • Book Title: Hematological Disorders in Children

  • Book Subtitle: Pathogenesis and Treatment

  • Editors: Eiichi Ishii

  • DOI: https://doi.org/10.1007/978-981-10-3886-0

  • Publisher: Springer Singapore

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Singapore Pte Ltd. 2017

  • Hardcover ISBN: 978-981-10-3885-3Published: 27 June 2017

  • Softcover ISBN: 978-981-10-9992-2Published: 22 August 2018

  • eBook ISBN: 978-981-10-3886-0Published: 14 June 2017

  • Edition Number: 1

  • Number of Pages: X, 269

  • Number of Illustrations: 18 b/w illustrations, 6 illustrations in colour

  • Topics: Hematology, Pediatrics, Oncology

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