Therapeutic Angiogenesis

1. Front Matter

   Pages i-vi

   PDF

2. Introduction Section: Overview of Therapeutic Angiogenesis

   • Yukihito Higashi, Toyoaki Murohara

   Pages 1-2

3. Cell Therapy

   1. Front Matter

      Pages 3-3

      PDF

   2. Autologous Bone Marrow Mononuclear Cell Implantation in Extremities with Critical Limb Ischemia

      • Kenji Yanishi, Satoaki Matoba

      Pages 5-23

   3. Peripheral Blood Mononuclear Cells for Limb Ischemia

      • Masayoshi Suda, Ippei Shimizu, Yohko Yoshida, Tohru Minamino

      Pages 25-43

   4. Endothelial Progenitor Cells for Ischemic Diseases

      • Takayuki Asahara, Haruchika Masuda

      Pages 45-66

   5. Therapeutic Angiogenesis with Adipose Tissue-Derived Regenerative Cells

      • Toyoaki Murohara, Kazuhisa Kondo

      Pages 67-79

   6. Cell Therapy for Ischemic Heart Disease

      • Hiroshi Kurazumi, Tohru Hosoyama, Kimikazu Hamano

      Pages 81-98

   7. Angiogenic Therapy for Ischemic Cardiomyopathy with Cell Sheet Technology

      • Shigeru Miyagawa, Yoshiki Sawa

      Pages 99-108

4. Gene Therapy

   1. Front Matter

      Pages 109-109

      PDF

   2. The Role of VEGF in the Extremities

      • Brendan A. S. McIntyre, Takayuki Asahara, Cantas Alev

      Pages 111-131

   3. HGF Gene Therapy for Therapeutic Angiogenesis in Peripheral Artery Disease

      • Jun Muratsu, Fumihiro Sanada, Yoshiaki Taniyama, Yuka Ikeda-Iwabu, Rei Otsu, Kana Shibata et al.

      Pages 133-144

   4. Fibroblast Growth Factor in Extremities

      • Michiko Tanaka, Yoshikazu Yonemitsu

      Pages 145-158

5. Other Therapy

   1. Front Matter

      Pages 159-159

      PDF

   2. Low-Intensity Pulsed Ultrasound

      • Akimichi Iwamoto, Takayuki Hidaka, Yasuki Kihara, Hiroshi Kubo, Yukihito Higashi

      Pages 161-175

   3. Low-Energy Extracorporeal Shock Wave Therapy

      • Kenta Ito, Tomohiko Shindo, Hiroaki Shimokawa

      Pages 177-190

   4. Granulocyte Colony-Stimulating Factor

      • Yasuyuki Fujita, Atsuhiko Kawamoto

      Pages 191-216

   5. Waon Therapy: Effect of Thermal Stimuli on Angiogenesis

      • Masaaki Miyata, Mitsuru Ohishi, Chuwa Tei

      Pages 217-227

   6. Exercise

      • Tatsuya Maruhashi, Yasuki Kihara, Yukihito Higashi

      Pages 229-245

   7. Nanoparticle-Mediated Endothelial Cell-Selective Drug Delivery System

      • Kaku Nakano, Jun-ichiro Koga, Kensuke Egashira

      Pages 247-266

The book discusses recent findings and current perspectives on therapeutic angiogenesis. Studies have shown that therapies such as cell implantation and transfer of gene encoding for angiogenic growth factors are effective in improving symptoms in patients with critical limb ischemia, who previously had no treatment option other than amputation. The book discusses these therapies and presents data collected in clinical studies over the past decade.


Despite significant advances in therapeutic angiogenesis since the first clinical studies in the early 21st century, it has been largely ignored in the literature. This comprehensive book fills that gap, making it a valuable resource for both researchers and practitioners alike.

• Ischemic symptoms
• Limb ischemia
• Arterial disease
• Cell implantation
• Gene coding for angiogenic growth factors
• Irradiation of pulsed ultrasound
• Shock wave
• Tissue engineering
• Waon therapy

“This is a fairly comprehensive review of all the different therapeutic modalities of stem cells in cardiovascular disease. … The audience includes any clinicians working in cardiovascular or peripheral vascular disease, heart failure, interventional cardiology, or vascular surgery, as well as those potentially looking to study this field in a purely research fashion, such as bench scientists or PhD candidates. … In general, this is a very helpful book for grasping the most current data on therapeutic angiogenesis.” (Merrill H. Stewart, Doody's Book Reviews, November, 2017)

• Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan

  Yukihito Higashi

• Department of Cardiology, Nagoya University, Aichi, Japan

  Toyoaki Murohara

Yukihito Higashi
Hiroshima University, Research Institute for Radiation Biology and Medicine


Toyoaki Murohara
Nagoya University, Department of Cardiology

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