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Hepatitis C Virus Treatment

Highly Effective Therapy with Direct Acting Antivirals and Associated Viral Resistance

  • Book
  • © 2017

Overview

Editors:
  1. Kazuaki Chayama

    1. Department of Gastroenterology and Metabolism, Hiroshima University, Hiroshima, Japan

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  • Introduces new therapies available for treating chronic hepatitis C
  • Describes Direct Acting Antiviral Agents (DAA), which have an excellent anti-viral effect on virus replication
  • Provides cutting-edge information not only for hepatologists, but also for researchers, clinical residents, and medical students

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-vii
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  2. Treatment of Chronic Hepatitis C with the First-Generation Protease Inhibitor Telaprevir: Its Efficacy and Resistance Mutations

    • Yoshiyasu Karino
    Pages 1-8

  3. Features of the Second Wave of the First Generation Protease Inhibitors: Effect and Tolerance

    • Tetsuo Takehara
    Pages 9-16

  4. The Efficacy of Daclatasvir Plus Asunaprevir Combination Therapy with Chronic Hepatitis

    • Fukiko Mitsui, C. Nelson Hayes, Fumitaka Suzuki, Kazuaki Chayama
    Pages 17-24

  5. Resistance-Associated Variants in the NS5A Region of HCV and Methods for the Detection

    • Satoshi Mochida
    Pages 25-32

  6. Detection of Antiviral Drug-Resistant Variants in Chronic Hepatitis C by Deep Sequencing

    • Shinya Maekawa, Mitsuaki Sato, Nobuyuki Enomoto
    Pages 33-43

  7. Incidence and Characteristics of Naturally Occurring Drug-Resistant Hepatitis C Virus Strains

    • Goki Suda, Jun Ito, Kenichi Morikawa, Koji Ogawa, Naoya Sakamoto
    Pages 45-50

  8. Treatment Effects and Resistance-Associated Variants of Sofosbuvir Regimen for Japanese Patients with Chronic Hepatitis C Virus Genotypes 1 and 2

    • C. Nelson Hayes, Masaaki Korenaga, Masashi Mizokami
    Pages 51-61

  9. Emerging Antivirals in the Future

    • C. Nelson Hayes, Michio Imamura, Kazuaki Chayama
    Pages 63-75
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Keywords

About this book

This book introduces readers to Direct Acting Antiviral (DAAs) agents, newly developed drugs to treat chronic hepatitis C virus infection, which have an excellent anti-viral effect on virus replication. These drugs have been developed to enhance the effect of interferon and ribavirin, as the resistant strains against each drug have been described both in vitro and in vivo and the existences of naturally occurring variants have been reported. However, since the combination of different classes of DAAs is sufficient to completely eradicate the virus without the need for interferon or ribavirin, the current treatment regimen does not include interferon. Ribavirin is used in combination with sofosbuvir, a potent polymerase inhibitor, to enhance its antiviral effects.

Hepatitis C Virus Treatment offers readers a comprehensive guide to hepatitis C; describing the resistance profiles against these drugs and shedding light on the difficulties involved in DAA therapy and the direction of future treatments, it will equip doctors to understand the essentials of treating the disease. It also describes in detail new and innovative DAA treatments, the effects of the agents, and the characteristics of resistance, providing cutting-edge information not only for hepatologists, but also for researchers, clinical residents, and medical students.

Editors and Affiliations

  • Department of Gastroenterology and Metabolism, Hiroshima University, Hiroshima, Japan

    Kazuaki Chayama

About the editor

Prof. Kazuaki ChayamaDepartment of Gastroenterology and Metabolism, Applied Life Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University

Bibliographic Information

  • Book Title: Hepatitis C Virus Treatment

  • Book Subtitle: Highly Effective Therapy with Direct Acting Antivirals and Associated Viral Resistance

  • Editors: Kazuaki Chayama

  • DOI: https://doi.org/10.1007/978-981-10-2416-0

  • Publisher: Springer Singapore

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Science+Business Media Singapore 2017

  • Hardcover ISBN: 978-981-10-2415-3Published: 14 November 2016

  • Softcover ISBN: 978-981-10-9610-5Published: 05 July 2018

  • eBook ISBN: 978-981-10-2416-0Published: 01 November 2016

  • Edition Number: 1

  • Number of Pages: VII, 75

  • Number of Illustrations: 9 b/w illustrations, 14 illustrations in colour

  • Topics: Hepatology, Virology, Drug Resistance

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