Fundamentals of MALDI-ToF-MS Analysis

1. Front Matter

   Pages i-xi

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2. Principles and Mechanism of MALDI-ToF-MS Analysis

   • Samira Hosseini, Sergio O. Martinez-Chapa

   Pages 1-19

3. Fundamentals of Biosensors and Application of MALDI-ToF-MS in Bio-diagnostic Domain

   • Samira Hosseini, Sergio O. Martinez-Chapa

   Pages 21-39

4. Fundamentals of Tissue Engineering and Application of MALDI-ToF-MS in Analysis of the Scaffold Materials

   • Samira Hosseini, Sergio O. Martinez-Chapa

   Pages 41-52

5. Fundamentals of Drug Delivery Systems and Application of MALDI-ToF-MS in Drug Delivery

   • Samira Hosseini, Sergio O. Martinez-Chapa

   Pages 53-66

6. Back Matter

   Pages 67-68

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This book presents the fundamentals and applications of Matrix Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-ToF-MS) technique. It highlights the basic principles, the history of invention as well as the mechanism of ionization and mass determination using this technique. It describes the fundamental principles and methods for MALDI spectra interpretation and determination of exact chemical structures from experimental data. This book guides the reader through the interpretation of MALDI data where complex macromolecular spectra are simplified in order to present the major principles behind data interpretation. In addition, each chapter describes how MALDI-ToF-MS analysis provides necessary understanding of the copolymer systems that have been designed for specialized biomedical applications.

• Time of Flight Mass Spectrometry
• Laser Range in MALDI
• Dried-droplet Analysis
• Electrospray Deposition
• Ionizing Agent Selection
• Fourier Transform Ion Cyclotron Resonance (FT-ICR)
• Size Exclusion Chromatograph (SEC)
• Tin Layer Chromatography (TLC)
• Synthesis of PMMA
• Elastomeric Films and Coatings

• School of Engineering and Sciences, Tecnológico de Monterrey School of Engineering and Sciences, Monterrey, Mexico

  Samira Hosseini, Sergio O. Martinez-Chapa

Dr. Samira Hosseini obtained her BSc degree in Applied Physics, her MSc degree in Polymer Chemistry and her PhD degree in Biomedical Engineering. Currently, she is working as a Postdoctoral Researcher at School of Engineering and Sciences, Tecnológico de  Monterrey, Mexico. Her main areas of  research are surface engineering, interface science, bioanalytical systems and polymeric materials.

Sergio O. Martinez is a professor of Electrical and Computer Engineering at Tecnológico de Monterrey, Monterrey Campus; and Chair of the Sensors and Devices of the National School of Engineering and Sciences at the same Institute. He obtained his Ph.D. in Microelectronics from the National Polytechnic Institute of Grenoble, France in 2002. He  is a member of the Mexican Research National System since 2004 and the Mexican Academy of Sciences since 2010. His recent research activities, focused on Micro/Nanotechnolgies, include Microfabrication Processes for Particle Manipulation Devices, Electrokinetically-driven Microdevices for Manipulation of Suspended Particles in Fluidic Media, and Modeling and Design of SPR-based Biosensing Platforms. He has been Principal Investigator in projects funded by CONACYT, the Mexican Economy Ministry, and the Bureau of Science and Technology of Nuevo Leon. He has authored/coauthored 75 peer-reviewed publications, 7 book chapters and 2 granted patents.

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