Overview
- Discusses the findings on the physiological and pathological functions of TRPCs in the brain
- Covering the potential roles of TRPCs in brain disorders
- Providing students and investigators with comprehensive information on regulation, function and potential of TRPCs and brain diseases?
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 976)
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Table of contents (14 chapters)
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Front Matter
Keywords
About this book
This book discusses the latest findings on the physiological and pathological functions of transient receptor potential canonical/classical (TRPC) proteins in the brain. In addition to reviewing the functions of TRPCs in brain development and neuron transmission, it mainly covers the potential roles of TRPCs in brain disorders. TRPC proteins belong to the TRP channel superfamily, which has around 30 members. Just like TRP channels, TRPCs are non-selectively permeable to cations, with a selectivity of calcium over sodium that varies among different members. The TRPC subfamily consists of six members, grouped on the basis of the similarities in gene sequence and protein structure in mammalians. What sets TRPCs apart from other subfamilies in TRPs is that their activation, stimulated by a membrane receptor-phospholipid C (PLC) cascade, contributes to the slow and sustained elevation of intracellular free calcium. Calcium ions, one of the most important types of second messengers, mediate a variety of physiological functions in the brain, including progenitor cell proliferation, dendritic formation, synaptic transmission and neuronal survival. All TRPCs except TRPC7 have been found in various regions of the brain, including the cerebrum, cerebellum, forebrain and hippocampus. This book provides students and investigators with comprehensive information on the regulation, function and potential of TRPCs and brain diseases in order to attract more attention to this field.
Editors and Affiliations
About the editor
Dr. Yizheng Wang is a senior investigator at the Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences. He is the leader of the Laboratory of Neuronal Signal Transduction and an executive director of the Chinese Society for Neuroscience and Chinese Society of Biochemistry and Molecular Biology. His research focuses on the function and regulation of TRPC channels in neural development and diseases, a field in which he has published more than 40 research articles.
Bibliographic Information
Book Title: Transient Receptor Potential Canonical Channels and Brain Diseases
Editors: Yizheng Wang
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-94-024-1088-4
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature B.V. 2017
Hardcover ISBN: 978-94-024-1086-0Published: 23 May 2017
Softcover ISBN: 978-94-024-1486-8Published: 09 May 2018
eBook ISBN: 978-94-024-1088-4Published: 15 May 2017
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: VIII, 165
Number of Illustrations: 1 b/w illustrations, 15 illustrations in colour
Topics: Neurosciences, Biochemistry, general, Cancer Research, Pharmacology/Toxicology