Urea Transporters

1. Front Matter

   Pages i-x

   PDF

2. Overview and Historical Perspective

   • Baoxue Yang, Jeff M. Sands

   Pages 1-5

3. Urea

   • Hongkai Wang, Jianhua Ran, Tao Jiang

   Pages 7-29

4. Mathematical Modeling of Urea Transport in the Kidney

   • Anita T. Layton

   Pages 31-43

5. Genes and Proteins of Urea Transporters

   • Jeff M. Sands, Mitsi A. Blount

   Pages 45-63

6. Structure of Urea Transporters

   • Elena J. Levin, Ming Zhou

   Pages 65-78

7. Expression of Urea Transporters and Their Regulation

   • Janet D. Klein

   Pages 79-107

8. Biochemical Properties of Urea Transporters

   • Guangping Chen

   Pages 109-126

9. Transport Characteristics of Urea Transporter-B

   • Baoxue Yang

   Pages 127-135

10. Urea Transporter Knockout Mice and Their Renal Phenotypes

    • Robert A. Fenton, Baoxue Yang

    Pages 137-152

11. Extrarenal Phenotypes of the UT-B Knockout Mouse

    • Baoxue Yang, Xin Li, Lirong Guo, Yan Meng, Zixun Dong, Xuejian Zhao

    Pages 153-164

12. Small-Molecule Inhibitors of Urea Transporters

    • Alan S. Verkman, Cristina Esteva-Font, Onur Cil, Marc O. Anderson, Fei Li, Min Li et al.

    Pages 165-177

13. Clinical Aspects of Urea Transporters

    • Jianhua Ran, Hongkai Wang, Tinghai Hu

    Pages 179-191

14. Active Urea Transport in Lower Vertebrates and Mammals

    • Lise Bankir

    Pages 193-226

15. Urea Transport Mediated by Aquaporin Water Channel Proteins

    • Chunling Li, Weidong Wang

    Pages 227-265

The mechanisms and physiological functions of urea transporters across biological membranes are subjects of long-standing interests. Although urea represents roughly 40% of all urinary solutes in normal human urine, the handling of urea in the tissues has been largely neglected in the past and few clinical or experimental studies now report data on urea. Most recent physiological text books include chapters on water and electrolyte physiology but no chapter on urea. Our aim in writing this book is to stimulate further research in new directions by providing novel and provocative insights into the further mechanisms and physiological significance of urea metabolism and transport in mammals. This book offers a state-of-the-art report on recent discoveries concerning urea transport and where the field is going. It mainly focuses on advances made over the past 20 years on the biophysics, genetics, protein structure, molecular biology, physiology, pathophysiology and pharmacology of urea transport in mammalian cell membranes. It will help graduate students and researchers to get an overall picture of mammalian urea transporters and may also yield benefits for pharmaceutical companies with regard to drug discovery based on the urea transporter. Baoxue Yang is a professor and vice chairman of the Department of Pharmacology, Peking University. He is also an adjunct professor of Jilin University and a visiting professor of Northeast Normal University. Prof. Yang has been researching urea transporters for nearly 20 years and has published more than 70 original research articles in this field.

• Membrane channel
• Transporter protein
• Urea
• Urea transporter
• Urine concentration

• School of Basic Medical Sciences, Department of Pharmacology, Peking University, Beijing, China

  Baoxue Yang

• Renal Division, Department of Medicine and Department of Physiology, Emory University School of Medicine, Atlanta, USA

  Jeff M. Sands

Baoxue Yang is a professor and vice chairman of Department of Pharmacology, Peking University. He is also an adjunct professor of Jilin University and a visiting professor of Northeast Normal University. Prof. Yang has been studying on urea transporter for nearly 20 years and published more than 70 original research articles in this field.

Jeff M. Sands is the Juha P. Kokko Professor of Medicine and Physiology, Director of the Renal Division, and Executive Vice-Chair of the Department of Medicine at Emory Universtiy School of Medicine. Dr. Sands' research focuses on urea transport proteins and the urine concentrating mechanisms.

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