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Issues in Clinical Epileptology: A View from the Bench

  • Book
  • © 2014

Overview

Editors:
  1. Helen E. Scharfman

    1. Dept. of Child & Adoles. Psych., Phys. & Neurosc., and Psych., New York Univ. Langone Med. Ctr., Orangeburg, USA

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  2. Paul S. Buckmaster

    1. Dept. of Comp. Med. and Neurol. & Neurol. Scs., Stanford University, Stanford, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Discussion of current debates in epilepsy research
  • Authors are leaders in the field of epilepsy and neuroscience
  • Basic and clinical research opinions are combined
  • Content provides a perspective on past literature
  • Chapters suggest future directions in epilepsy research

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 813)

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Table of contents (26 chapters)

  1. Front Matter

    Pages i-xxi
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  2. Seizures, Epileptiform Activities, and Regional Localization

    1. Front Matter

      Pages 1-1
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    2. How Can We Identify Ictal and Interictal Abnormal Activity?

      • Robert S. Fisher, Helen E. Scharfman, Marco deCurtis
      Pages 3-23

    3. What Is the Clinical Relevance of In Vitro Epileptiform Activity?

      • Uwe Heinemann, Kevin J. Staley
      Pages 25-41

    4. What Is the Importance of Abnormal “Background” Activity in Seizure Generation?

      • Richard J. Staba, Gregory A. Worrell
      Pages 43-54

    5. What Is a Seizure Focus?

      • J. Victor Nadler, Dennis D. Spencer
      Pages 55-62

    6. What Is a Seizure Network? Long-Range Network Consequences of Focal Seizures

      • Hal Blumenfeld
      Pages 63-70

    7. What Is a Seizure Network? Very Fast Oscillations at the Interface Between Normal and Epileptic Brain

      • Roger D. Traub, Mark O. Cunningham, Miles A. Whittington
      Pages 71-80

    8. Is There Such a Thing as “Generalized” Epilepsy?

      • Gilles van Luijtelaar, Charles Behr, Massimo Avoli
      Pages 81-91

  3. Synaptic Plasticity

    1. Front Matter

      Pages 93-93
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    2. Are There Really “Epileptogenic” Mechanisms or Only Corruptions of “Normal” Plasticity?

      • Giuliano Avanzini, Patrick A. Forcelli, Karen Gale
      Pages 95-107

    3. When and How Do Seizures Kill Neurons, and Is Cell Death Relevant to Epileptogenesis?

      • Ray Dingledine, Nicholas H. Varvel, F. Edward Dudek
      Pages 109-122

    4. How Is Homeostatic Plasticity Important in Epilepsy?

      • John W. Swann, Jong M. Rho
      Pages 123-131

    5. Is Plasticity of GABAergic Mechanisms Relevant to Epileptogenesis?

      • Helen E. Scharfman, Amy R. Brooks-Kayal
      Pages 133-150

    6. Do Structural Changes in GABA Neurons Give Rise to the Epileptic State?

      • Carolyn R. Houser
      Pages 151-160

    7. Does Mossy Fiber Sprouting Give Rise to the Epileptic State?

      • Paul S. Buckmaster
      Pages 161-168

    8. Does Brain Inflammation Mediate Pathological Outcomes in Epilepsy?

      • Karen S. Wilcox, Annamaria Vezzani
      Pages 169-183

    9. Are Changes in Synaptic Function That Underlie Hyperexcitability Responsible for Seizure Activity?

      • John G. R. Jefferys
      Pages 185-194

    10. Does Epilepsy Cause a Reversion to Immature Function?

      • Aristea S. Galanopoulou, Solomon L. Moshé
      Pages 195-209

    11. Are Alterations in Transmitter Receptor and Ion Channel Expression Responsible for Epilepsies?

      • Kim L. Powell, Katarzyna Lukasiuk, Terence J. O’Brien, Asla Pitkänen
      Pages 211-229
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Keywords

About this book

This book is dedicated to Dr. Philip A. Schwartzkroin. The book has a novel format because it is not intended to be a set of reviews. Instead, it is an effort to explore important topics in the epilepsy research field. Because articles are written by leaders in the field who have years of experience and individuals with diverse expertise, articles are likely to have a long-lasting impact and be relevant for both epileptologists and neuroscientists. Authors address topics that are important, unresolved questions in the field of epilepsy research, drawing on available data from both the bench and the clinic to support their points. A given topic is addressed by one or more authors, each writing from his/her own unique perspective. For all of the individuals who have been trained or worked with Philip Schwartzkroin in the past and/or have appreciated his contributions to the epilepsy field, this volume is an excellent way to celebrate his achievements and look to the ways they have moved the field forward and continue to stimulate its growth.

Editors and Affiliations

  • Dept. of Child & Adoles. Psych., Phys. & Neurosc., and Psych., New York Univ. Langone Med. Ctr., Orangeburg, USA

    Helen E. Scharfman

  • Dept. of Comp. Med. and Neurol. & Neurol. Scs., Stanford University, Stanford, USA

    Paul S. Buckmaster

Bibliographic Information

  • Book Title: Issues in Clinical Epileptology: A View from the Bench

  • Editors: Helen E. Scharfman, Paul S. Buckmaster

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-94-017-8914-1

  • Publisher: Springer Dordrecht

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature B.V. 2014

  • Hardcover ISBN: 978-94-017-8913-4Published: 11 July 2014

  • Softcover ISBN: 978-94-024-0789-1Published: 23 August 2016

  • eBook ISBN: 978-94-017-8914-1Published: 10 July 2014

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XXI, 339

  • Number of Illustrations: 29 b/w illustrations, 21 illustrations in colour

  • Topics: Neurology, Neurosciences, Neurobiology, Neurosurgery, Epidemiology

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