Overview
- A comprehensive overview of one of the largest pore forming proteins superfamilies
- A special chapter on methodology allowing the study of mechanisms of pore formation
- Several novel data reviews which provide new insights into the distribution of MACPF/CDC proteins throughout biology
- In depth perspectives on MACPF/CDCs from multiple fields of study: medicine, biology, biophysics, applications-based, technical development
- Includes supplementary material: sn.pub/extras
Part of the book series: Subcellular Biochemistry (SCBI, volume 80)
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Table of contents (15 chapters)
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Front Matter
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Overview of MACPF/CDCs
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Front Matter
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Structures of MACPF/CDCs
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Front Matter
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Functional Aspects of MACPF/CDCs
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Front Matter
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Back Matter
Keywords
About this book
This book focusses on evolutionary, structural and functional aspects of pore-forming proteins, bringing together prominent researchers in the fields of structural biology and cellular and biophysical techniques. The focus is on the MACPF/CDC protein super family that was originally discovered because of unexpected structural similarity between a domain present in bacterial cholesterol-dependent cytolysins (CDC) and proteins of the membrane attack complex/perforin (MACPF) family. Members of the MACPF/CDC super family are crucial for many biological processes, being efficient agents of development, defence, attack and invasion of cells and tissues. However, their best-known role is in bacterial pathogenesis and the proper functioning of the vertebrate immune system, via formation of transmembrane pores in target cell membranes.
The book contains chapters on the distribution of MACPF/CDC proteins and on aspects of their evolution and structural properties, the similarities between different super family members and functional properties of some of the best known examples. The book also contains an overview of biophysical approaches that may be used in the future to provide further insights into how these interesting proteins function.
Editors and Affiliations
Bibliographic Information
Book Title: MACPF/CDC Proteins - Agents of Defence, Attack and Invasion
Editors: Gregor Anderluh, Robert Gilbert
Series Title: Subcellular Biochemistry
DOI: https://doi.org/10.1007/978-94-017-8881-6
Publisher: Springer Dordrecht
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Science+Business Media Dordrecht 2014
Hardcover ISBN: 978-94-017-8880-9Published: 19 May 2014
Softcover ISBN: 978-94-024-0339-8Published: 03 September 2016
eBook ISBN: 978-94-017-8881-6Published: 05 May 2014
Series ISSN: 0306-0225
Series E-ISSN: 2542-8810
Edition Number: 1
Number of Pages: XI, 329
Number of Illustrations: 5 b/w illustrations, 52 illustrations in colour
Topics: Biomedicine general, Medicine/Public Health, general, Science, Humanities and Social Sciences, multidisciplinary, Chemistry/Food Science, general, Entomology, Pharmacy