Adult and Pluripotent Stem Cells

1. Front Matter

   Pages i-xii

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2. Mesenchymal Stem Cells for Cardiac Repair: Preclinical Models of Disease

   • Manuel Mazo, Miriam Araña, Beatriz Pelacho, Felipe Prosper

   Pages 1-19

3. Resident Cardiac Progenitor Cells

   • Ayelet Itzhaki-Alfia, Jonathan Leor

   Pages 21-35

4. Endothelial Progenitor Cells Derived from Cord or Peripheral Blood and Their Potential for Regenerative Therapies

   • Renate Hofer-Warbinek, Caterina Sturtzel, Karl-Heinz Preisegger, Erhard Hofer

   Pages 37-51

5. Adipose-derived Stromal/Stem Cells and Their Differentiation Potential into the Endothelial Lineage

   • Patrick C. Baer, Werner Luttmann

   Pages 53-70

6. Cardiac Cell Replacement Therapy With Pluripotent Stem Cell Derived Cardiomyocytes

   • Benjamin Krausgrill, Marcel Halbach, Jürgen Hescheler

   Pages 71-82

7. Biomaterials for Cardiac Tissue Engineering and Regeneration

   • Emil Ruvinov, Smadar Cohen

   Pages 83-111

8. Cell Therapy of Acute Myocardial Infarction and Ischemic Cardiomyopathy: From Experimental Findings to Clinical Trials

   • Stefan P. Janssens

   Pages 113-141

9. Clinical Gene and Stem Cell Therapy in Patients with Acute and Chronic Myocardial Ischemia

   • Jens Kastrup, Annette Ekblond, Mandana Haack-Sørensen, Anders B. Mathiasen, Abbas A. Qayyum

   Pages 143-167

10. Back Matter

    Pages 169-170

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There is hardly an area of research developing so quickly and raising so many promises as stem cell research. Adult, embryonic and recently available induced pluripotent stem cells not only foster our understanding of differentiation of endo-, ecto- and mesodermal lineages to all organs of the body, but foremost nourish the hope that cells grown in culture can be used for regeneration of diseased organs such as the heart damaged by myocardial infarction. This book focuses on perspectives of stem cells for regenerative therapy of cardiovascular diseases. Based on the EC consortium INELPY, it reviews the field and disseminates major outcomes of this project. Thus it introduces the reader to this fascinating area of research and incorporates very recent findings interesting to the expert, spanning the field from bench to bedside. The compilation of contributions is unique as there is yet no similar comprehensive overview combining stem cell research with preclinical and clinical evaluation as well as engineering of tissue patches for transplantation. As such it will be an invaluable source of information for all researchers in the stem cell and tissue regeneration field including bioengineers as well as for all clinicians interested in regenerative therapies, especially for ischemic cardiomyopathies.

• induced pluripotent stem cells (iPS cells)
• regeneration of brain cells
• regeneration of diseased organs
• spermatogonial stem cells
• transplantation

• University of Cologne, Germany

  Jürgen Hescheler

• Medical University of Vienna, Austria

  Erhard Hofer

Policies and ethics