Neuronal Tissue-Nonspecific Alkaline Phosphatase (TNAP)

1. Front Matter

   Pages i-xxii

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2. Disease Forms and Animal Models of Hypophosphatasia

   1. Front Matter

      Pages 1-1

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   2. Clinical Forms and Animal Models of Hypophosphatasia

      • Jean Pierre Salles

      Pages 3-24

   3. Molecular Genetics of Hypophosphatasia and Phenotype-Genotype Correlations

      • Etienne Mornet

      Pages 25-43

   4. Genetically Modified Mice for Studying TNAP Function

      • Sonoko Narisawa

      Pages 45-57

3. Expression and Regulation of TNAP in the Central Nervous System

   1. Front Matter

      Pages 59-59

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   2. Tissue-Nonspecific Alkaline Phosphatase in the Developing Brain and in Adult Neurogenesis

      • Herbert Zimmermann, David Langer

      Pages 61-84

   3. Rediscovering TNAP in the Brain: A Major Role in Regulating the Function and Development of the Cerebral Cortex

      • Caroline Fonta, Pascal Barone, Laia Rodriguez Martinez, László Négyessy

      Pages 85-106

   4. The Retinal TNAP

      • Orsolya Kántor, Dorottya Cserpán, Béla Völgyi, Ákos Lukáts, Zoltán Somogyvári

      Pages 107-123

   5. Tissue Non-specific Alkaline Phosphatase (TNAP) in Vessels of the Brain

      • Barbara Deracinois, Anne-Marie Lenfant, Marie-Pierre Dehouck, Christophe Flahaut

      Pages 125-151

4. TNAP Functions in the Nervous System

   1. Front Matter

      Pages 153-153

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   2. What Can We Learn About the Neural Functions of TNAP from Studies on Other Organs and Tissues?

      • José Luis Millán

      Pages 155-166

   3. TNAP, an Essential Player in Membrane Lipid Rafts of Neuronal Cells

      • Myriam Ermonval, Florence Baychelier, Caroline Fonta

      Pages 167-183

   4. Signal Transduction Pathways of TNAP: Molecular Network Analyses

      • László Négyessy, Balázs Györffy, János Hanics, Mihály Bányai, Caroline Fonta, Fülöp Bazsó

      Pages 185-205

   5. Vitamin B-6 Metabolism and Interactions with TNAP

      • Stephen P. Coburn

      Pages 207-238

   6. Tetramisole and Levamisole Suppress Neuronal Activity Independently from Their Inhibitory Action on Tissue Non-specific Alkaline Phosphatase in Mouse Cortex

      • Lionel G. Nowak, Benoît Rosay, Dávid Czégé, Caroline Fonta

      Pages 239-281

   7. TNAP and Pain Control

      • Sarah E. Street, Nathaniel A. Sowa

      Pages 283-305

5. TNAP in Neurological Disorders

   1. Front Matter

      Pages 307-307

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   2. Neurological Symptoms of Hypophosphatasia

      • Takeshi Taketani

      Pages 309-322

   3. Recombinant Enzyme Replacement Therapy in Hypophosphatasia

      • Christine Hofmann, Franz Jakob, Lothar Seefried, Birgit Mentrup, Stephanie Graser, Horacio Plotkin et al.

      Pages 323-341

Phosphatases, such as TNAP are fundamental in regulating the roles of cellular, and consequently numerous body functions. TNAP is a ubiquitous enzyme with a wide spectrum of substrates and specificity. Regulation at the cellular level and the lack of TNAP activity is a lethal condition. Recent findings of a highly specific regional, laminar and subcellular localization of TNAP in the cerebral cortex indicates that in addition to its metabolic and skeletal functions, TNAP also plays a role in regulating cerebral functions, most probably cognition. In fact, TNAP disturbance could result in complex diseases such as epilepsy, developmental retardation and Alzheimer's disease. Available data suggest that, regarding brain functions, TNAP is a potentially important target of clinical research. This book aims to provide an overview of our current understanding of the functions of TNAP in the brain and on other tissues and organs.

• Brain development
• Cerebral cortex
• Epilepsy
• Metabolic disorders
• Neurobiology

• National Centre for Scientific Research (CNRS), University of Toulouse-UPS, Toulouse, France

  Caroline Fonta

• Wigner Research Centre for Physics, Hungarian Academy of Sciences, Budapest, Hungary

  László Négyessy

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