The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals

1. Front Matter

   Pages I-XI

   PDF

2. The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals

   • V. J. Feron

   Pages 1-5

3. Physiologically Based Pharmacokinetic Modeling of the Glycol Ether, 2-butoxethanol, and Its Application in Human Health Risk Assessments and Exposure Guidelines

   • Richard A. Corley

   Pages 7-39

4. Application of Pharmacokinetic Modelling to Biological Monitoring

   • Pierre O. Droz

   Pages 41-53

5. Dermal Absorption from Pesticide Residues

   • Micaela B. Reddy, Annette Bunge

   Pages 55-78

6. Inter-Species Pharmacokinetic Comparison of Organic Acid Herbicides. Is the Dog a Relevant Species for Evaluation of Human Health Risk?

   • Charles Timchalk, Richard Nolan, Richard Billington, David L. Eisenbrandt

   Pages 79-107

7. Modeling the Uptake and Disposition of Hydrophobic Organic Chemicals in Fish Using a Physiologically Based Approach

   • John W. Nichols

   Pages 109-133

8. Chair’s Introduction to the Second Symposium day

   • Peter C. Bragt

   Pages 135-139

9. Can Biologically Based Models of Carcinogenesis Be Used for Risk Assessment ?

   • Annette Kopp-Schneider

   Pages 141-153

10. The Prediction of Systemic Toxicity by Integrating the Results of Biokinetic Models and Biologically Based In Vitro Test Methods

    • Bas J. Blaauboer, Joost DeJongh, Anna Forsby, J. Brian Houston, André Guillouzo, Martin D. Barratt et al.

    Pages 155-194

In 2000 OpdenKamp Registration & Notification organized a two-day symposium in The Hague, The Netherlands, on `The Practical Applicability of Toxicokinetic Models in the Risk Assessment of Chemicals'. Several speakers from Europe and the United States were invited to present the different aspects. A vast range of areas was discussed in relation to toxicological modeling and risk assessment, such as occupational toxicology and biomonitoring, exposure to organic solvents and crop protection products, dose-response relations in carcinogenicity, regulatory toxicology, estimation of dermal penetration, uptake and disposition of organic chemicals in fish, the possibilities of in vitro methods in hazard and risk assessment, and the extrapolation between animal and human species. Based on their presentations, the speakers prepared comprehensive papers for this symposium book, reflecting the state of the art of modeling and toxicological risk assessment at the beginning of the third millennium.

• absorption
• assessment
• biomonitoring
• ethanol
• pesticide
• research
• toxicity
• toxicology

• OpdenKamp Registration & Notification, The Hague, The Netherlands

  Jacob Krüse, Henk J. M. Verhaar, W. K. Raat

Policies and ethics