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Multiple Drug Resistance in Cancer 2

Molecular, Cellular and Clinical Aspects

  • Book
  • © 1998

Overview

Editors:
  1. Martin Clynes

    1. National Cell & Tissue Center, Bioresearch Ireland, Dublin City University, Glasnevin, Dublin, Ireland

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. P-glycoprotein structure and evolutionary homologies

    • Irene Bosch, James M. Croop
    Pages 1-30

  3. Molecular analysis of the multidrug transporter, P-glycoprotein

    • Ursula A. Germann, Timothy C. Chambers
    Pages 31-60

  4. Mutagenesis of the putative nucleotide-binding domains of the multidrug resistance associated protein (MRP). Analysis of the effect of these mutations on MRP mediated drug resistance and transport

    • Melvin S. Center, Qichao Zhu, Hongwei Sun
    Pages 61-69

  5. Membrane topology of the human multidrug resistance-associated protein (MRP) and its homologs

    • András Váradi, Gábor E. Tusnády, Éva Bakos, Balázs Sarkadi
    Pages 71-79

  6. A new aspect on glutathione-associated biological function of MRP/GS-X pump and its gene expression

    • Toshihisa Ishikawa, M. Tien Kuo, Kyoji Furuta, Masaaki Suzuki
    Pages 81-93

  7. Intracellular distribution of anthracyclines in drug resistant cells

    • Giuseppe Arancia, Annarica Calcabrini, Stefania Meschini, Agnese Molinari
    Pages 95-111

  8. Use of ribozymes and antisense oligodeoxynucleotides to investigate mechanisms of drug resistance

    • Daragh Byrne, Carmel Daly, Roisin NicAmhlaoibh, Anthony Howlett, Kevin Scanlon, Martin Clynes
    Pages 113-136

  9. Vault-related resistance to anticancer drugs determined by the expression of the major vault protein LRP

    • Miguel A. Izquierdo, George L. Scheffer, Anouk B. Schroeijers, Mariska C. de Jong, Rik J. Scheper
    Pages 137-148

  10. Topoisomerase I inhibitors and drug resistance

    • Ralph E. Parchment, Augusto Pessina
    Pages 149-164

  11. Mechanisms of resistance to alkylating agents

    • G. Damia, M. D’Incalci
    Pages 165-173

  12. Drug resistance and DNA repair in leukaemia

    • Mark R. Müller, Jürgen Thomale, Manfred F. Rajewsky, Siegfried Seeber
    Pages 175-185

  13. Nucleotide excision repair and anti-cancer chemotherapy

    • Eddie Reed
    Pages 187-201

  14. Protein kinases and multidrug resistance

    • Martin G. Rumsby, Lisa Drew, J. Roger Warr
    Pages 203-224

  15. New insights into the kinetic resistance to anticancer agents

    • Bruno Chauffert, Marie-Thérèse Dimanche-Boitrel, Carmen Garrido, Mikael Ivarsson, Monique Martin, François Martin et al.
    Pages 225-235

  16. The extended-MDR phenotype

    • Ross Davey, Mary Davey
    Pages 237-247

  17. Role of oxygenation and vascularization in drug resistance

    • Jürgen Mattern, Manfred Volm
    Pages 249-256

  18. Transcriptional regulation of MDR genes

    • Kathleen W. Scotto, David A. Egan
    Pages 257-269

  19. Cytokine-mediated reversal of multidrug resistance

    • Ulrike Stein, Wolfgang Walther
    Pages 271-282

  20. The role of oncogenes in drug resistance

    • Dihua Yu
    Pages 283-292
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Keywords

About this book

Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently discovered mechanisms relating to oncogene expression and in particular to proteins involved in regulation and execution of apoptosis. Other important topics covered include DNA repair, topoisomerases, cell cycle control, oxygenation and vascularisation of tumours, LRP, intermediate filament proteins and low-level resistance. Recent developments in understanding the role of efflux pumps (P-170, MRP) in multi-drug resistance are also reviewed. This book will be useful to clinicians and scientists working in the areas of chemotherapy, drug resistance, DNA repair and apoptosis research.

Editors and Affiliations

  • National Cell & Tissue Center, Bioresearch Ireland, Dublin City University, Glasnevin, Dublin, Ireland

    Martin Clynes

Bibliographic Information

  • Book Title: Multiple Drug Resistance in Cancer 2

  • Book Subtitle: Molecular, Cellular and Clinical Aspects

  • Editors: Martin Clynes

  • DOI: https://doi.org/10.1007/978-94-017-2374-9

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media B.V. 1998

  • Hardcover ISBN: 978-0-7923-5272-3Published: 31 January 1999

  • Softcover ISBN: 978-90-481-5108-0Published: 01 December 2010

  • eBook ISBN: 978-94-017-2374-9Published: 17 April 2013

  • Edition Number: 1

  • Number of Pages: XI, 344

  • Topics: Cancer Research, Oncology, Pharmacology/Toxicology, Biochemistry, general

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