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Homocysteine and Vascular Disease

  • Book
  • © 2000

Overview

Editors:
  1. Killian Robinson

    1. Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 230)

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-xx
    Download chapter PDF

  2. Introduction

    • Ian Graham, Killian Robinson
    Pages 1-4

  3. Historical Aspects of the Relationship between Homocysteine and Vascular Disease

    • David E. L. Wilcken
    Pages 5-14

  4. Biochemistry and Metabolism

    • Donald W. Jacobsen
    Pages 15-39

  5. Reference Ranges for Homocysteine Concentrations

    • Johan B. Ubbink, Rhena Delport
    Pages 41-57

  6. Determinants of Plasma Homocysteine

    • Per Magne Ueland, Helga Refsum, Jørn Schneede
    Pages 59-84

  7. Epidemiology of Homocysteine Levels and Relation to Vitamins

    • Peter W. F. Wilson, Paul F. Jacques
    Pages 85-95

  8. Vascular Pathology of Hyperhomocysteinemia

    • Kilmer S. McCully
    Pages 97-116

  9. Vascular Complications of Homocystinuria: Incidence, Clinical Pattern and Treatment

    • Paolo Rubba, Giovanni Di Minno, Generoso Andria
    Pages 117-133

  10. Homocysteine as a Risk Factor for Peripheral Vascular Disease

    • Ahmed M. Abou-Zamzam Jr., Gregory L. Moneta, John M. Porter, Lloyd M. Taylor Jr.
    Pages 135-149

  11. Homocysteine as a Risk Factor for Cerebrovascular Disease and Stroke

    • Ivan J. Perry
    Pages 151-172

  12. Homocysteine as a Risk Factor for Coronary Artery Disease

    • P. Barton Duell, M. René Malinow
    Pages 173-202

  13. Homocysteine and Family History of Coronary Artery Disease

    • Jacques Genest Jr.
    Pages 203-216

  14. Homocysteine as a Risk Factor for Cardiovascular Disease in Women

    • Petra Verhoef
    Pages 217-238

  15. Homocysteine and Venous Thrombosis

    • Martin Den Heijer
    Pages 239-252

  16. Homocysteine and Renal Disease

    • Killian Robinson, Vincent W. Dennis
    Pages 253-270

  17. Molecular Biology of Methylenetetrahydrofolate Reductase (MTHFR): Interrelationships with Folic Acid, Homocysteine and Vascular Disease

    • Rima Rozen
    Pages 271-289

  18. Molecular Biology of Methionine Synthase: Interrelationships with Homocysteine and Vascular Disease

    • Ruma Banerjee
    Pages 291-311

  19. Molecular Biology of Cystathionine β-Synthase: Interrelationships with Homocysteine, Pyridoxine, and Vascular Disease

    • Warren D. Kruger, Brian Fowler
    Pages 313-333

  20. Homocysteine and Cholesterol: Basic and Clinical Interactions

    • Henk J. Blom
    Pages 335-348
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Keywords

About this book

This is an important and timely volume. The history of research in homocysteine metabolism can be divided into three periods. The first phase was the exploration of the individual reactions and metabolites that characterize the transmethylation and transsulfuration sequences. The former originated with his description of the biosynthesis of methylpyridine and culminated in the work of Cantoni and Axelrod. Similarly the finding that insulin contained cystine was a potent catalyst for the metabolic and nutritional studies of Rose and du Vigneaud. The description and the definition of homocystinuria, a rare inherited meta­ bolic disorder, marked the beginning of the second historical period. Where previously there had been few laboratories located largely in the United States soon there were numerous research groups representing many nationalities. The more intense focus led to major advances, both in the laboratory and in the clinics. Studies of afflicted individuals, when combined with investigations in experimental animals, provided the basis for a concept of methionine metabo­ lism that encompassed both transmethylation and transsulfuration. The central role of homocysteine was apparent.

Reviews

`The book is therefore a great reference for an up-to-date review of any one of the many pathways involved in homocysteine metabolism. The editor should be applauded for bringing together some of the leaders in the field of homocysteine research and thus compiling a comprehensive review that should be on the shelf of any scientist working in the area of homocysteine.'
Clinical Chemistry, 47:6 (2001)

Editors and Affiliations

  • Department of Cardiology, The Cleveland Clinic Foundation, Cleveland, USA

    Killian Robinson

Bibliographic Information

  • Book Title: Homocysteine and Vascular Disease

  • Editors: Killian Robinson

  • Series Title: Developments in Cardiovascular Medicine

  • DOI: https://doi.org/10.1007/978-94-017-1789-2

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media Dordrecht 2000

  • Hardcover ISBN: 978-0-7923-6248-7Published: 30 April 2000

  • Softcover ISBN: 978-90-481-5431-9Published: 04 December 2010

  • eBook ISBN: 978-94-017-1789-2Published: 17 April 2013

  • Series ISSN: 0166-9842

  • Edition Number: 1

  • Number of Pages: XX, 448

  • Topics: Cardiology

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