Cerebral Amyloid Angiopathy in Alzheimer’s Disease and Related Disorders

1. Front Matter

   Pages i-xix

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2. Clinical Aspects of CAA and CAA-Related Hemorrhage

   1. Front Matter

      Pages 1-1

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   2. Clinical Aspects and Diagnostic Criteria of Sporadic CAA-Related Hemorrhage

      • Steven M. Greenberg

      Pages 3-19

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   3. Diagnosis of CAA during Life

      • Ulrich Bickel

      Pages 21-41

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   4. Vascular Risk Factors for Alzheimer’s Disease

      • Monique M. B. Breteler

      Pages 43-58

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   5. Cerebral Microvascular and Macrovascular Disease in the Aging Brain; Similarities and Differences

      • Harry V. Vinters

      Pages 59-78

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3. Genetics of CAA

   1. Front Matter

      Pages 79-79

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   2. APOE Genotype in Relation to Sporadic and Alzheimer-Related CAA

      • Mark O. McCarron, James A. R. Nicoll

      Pages 81-102

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   3. Clinical and Genetic Aspects of Hereditary Cerebral Hemorrhage with Amyloidosis Dutch Type (HCHW A-D)

      • Marjolijn Bornebroek, Joost Haan, Egbert Bakker, Raymund A. C. Roos

      Pages 103-119

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   4. Genetics and Neuropathology of Hereditary Cystatin C Amyloid Angiopathy (HCCAA)

      • Ísleifur Ólafsson, Leifur Thorsteinsson

      Pages 121-134

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4. Cellular and Molecular Pathology of CAA

   1. Front Matter

      Pages 135-135

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   2. Neuropathologic Features and Grading of Alzheimer-Related and Sporadic CAA

      • Harry V. Vinters, Jean-Paul G. Vonsattel

      Pages 137-155

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   3. Chemical Analysis of Amyloid β Protein in CAA

      • Alex E. Roher, Yu-Min Kuo, Alexander A. Roher, Mark R. Emmerling, Warren J. Goux

      Pages 157-177

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   4. Immunohistochemical Analysis of Amyloid β-Protein Isoforms in CAA

      • Haruyasu Yamaguchi, Marion L. C. Maat-Schieman

      Pages 179-188

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   5. Blood Brain Barrier Dysfunction and Cerebrovascular Degeneration in Alzheimer’s Disease

      • Raj N. Kalaria

      Pages 189-206

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   6. Aβ-Associated Proteins in Cerebral Amyloid Angiopathy

      • Robert M. W. De Waal, Marcel M. Verbeek

      Pages 207-221

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   7. Neuropathology of Hereditary Cerebral Hemorrhage with Amyloidosis-Dutch Type

      • Marion L. C. Maat-Schieman, Sjoerd G. Van Duinen, Remco Natté, Raymund A. C. Roos

      Pages 223-236

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   8. Neuropathology and Genetics of Prion Protein and British Cerebral Amyloid Angiopathies

      • Bernardino Ghetti, Pedro Piccardo, Blas Frangione, Rubén Vidal, Jorge Ghiso

      Pages 237-247

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5. In Vitro and Animal Models of CAA

   1. Front Matter

      Pages 249-249

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   2. Amyloid β Protein Internalization and Production by Canine Smooth Muscle Cells

      • Reinhard Prior, Britta Urmoneit

      Pages 251-264

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Cerebral amyloid angiopathy (CAA) is a distinctive abnormality of small cerebral blood vessels, one that has intrigued neuroscientists for decades. The time seems right for a book which examines the phenomenon of CAA using a multifaceted approach: What does it produce clinically? How might CAA be imaged? What are the crucial biochemical/cellular events within cerebral vessel walls that lead to CAA? How can in vitro or transgenic experimental systems be used to understand the etiology of, or even potential treatments for, CAA? The editors have assembled key figures in the field of CAA research to examine these (and other) questions in a series of focused chapters that address specific issues of importance in understanding CAA and its clinical manifestations. Comprehending the biology and pathogenesis of this fascinating vascular lesion may even provide clues to less common forms of cerebral microvascular disease that have been recognized for decades (hypertensive microangiopathy) or more recently (CADASIL).

• Alzheimer
• Grading
• Lipoprotein
• alzheimer's disease
• brain
• genetics
• hereditary cerebral hemorrhage
• molecular pathology
• muscle
• neuropathology
• pathogenesis
• vascular disease

`Meantime, this book offers good value for money for those clinicians and scientists interested in the current state of play.'
Brain, 124 (2001)

• Departments of Neurology and Pathology, University Medical Center St. Radboud, Nijmegen, The Netherlands

  Marcel M. Verbeek

• Department of Pathology, University Medical Center St. Radboud, Nijmegen, The Netherlands

  Robert M. W. Waal

• UCLA Medical Center, Los Angeles, USA

  Harry V. Vinters

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