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Animal models in cardiovascular research

  • Book
  • © 1994

Overview

Authors:
  1. David R. Gross

    1. Cardiovascular and Thoracic, Surgery Research Labs, University of Kentucky, Lexington, USA

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Part of the book series: Developments in Cardiovascular Medicine (DICM, volume 153)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xvii
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  2. General principles of animal selection, preoperative care, preanesthesia, chemical restraint and analgesia

    • David R. Gross
    Pages 1-12

  3. Cardiovascular effects of the opiods

    • David R. Gross
    Pages 13-68

  4. Cardiovascular effects of the tranquilizers

    • David R. Gross
    Pages 69-123

  5. Cardiovascular effects of other drugs commonly used in cardiovascular research

    • David R. Gross
    Pages 125-185

  6. General anesthesia

    • David R. Gross
    Pages 187-192

  7. Cardiovascular effects of intravenous anesthetic agents

    • David R. Gross
    Pages 193-233

  8. Cardiovascular effects of inhalant anesthetic agents

    • David R. Gross
    Pages 235-301

  9. Cardiovascular effects of hallucinogens, neurolept analgesic/anesthetic combinations and steroid anesthetics

    • David R. Gross
    Pages 303-342

  10. Normal cardiovascular parameters from intact, awake animals

    • David R. Gross
    Pages 343-402

  11. Naturally occurring models of cardiovascular disease

    • David R. Gross
    Pages 403-419

  12. Iatrogenic models for studying heart disease

    • David R. Gross
    Pages 421-461

  13. Animal models of atherosclerosis

    • David R. Gross
    Pages 463-474

  14. Animal models of hypertension

    • David R. Gross
    Pages 475-482

  15. Back Matter

    Pages 483-501
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Keywords

About this book

Interest in the humane and scientifically justifiable use of research animals has intensified since the publication of the first edition of this textbook. This completely revised and updated text provides information essential to any researcher interested in using animal models for cardiovascular research, or any research which requires normal cardiovascular function. The format and presentation have been changed to make the text more easy to read and use. An introductory chapter offers general principles of animal selection, pre and post-operative care, preanesthesia, chemical restraint, analgesia, and the recognition of pain. The number of references cited has been almost doubled over the previous text and the chapter tabulating normal cardiovascular parameters from intact, awake animals, of those species commonly used in research, has been greatly expanded. Other chapters providing comprehensive data on the cardiovascular effects of opioids, tranquilizers, anesthetic agents and other drugs commonly used in cardiovascular research have been expanded with special emphasis on species variability to drug effects. The chapters on both naturally occurring and iatrogenic models of cardiovascular disease have also been expanded and updated.

Reviews

`Every once in a while, one finds a text that is likely to be truly useful and a valuable addition to one's personal library. For those of us involved in cardiovascular research involving the use of whole animal models, such is this text.
Each chapter is prefaced with information of practical value for the researcher. The tables are subdivided by animal species and drug. ... This will be of tremendous value for anybody who is thinking about using a particular animal model for a research project and may save a good deal of time and effort.
For those of us who review grants and manuscripts for publication, this text should serve as a useful reference for normal values and for comparative studies so as to determine whether or not the work in question reflects a typical situation.
... the text is likely to be of considerable use and is highly recommended as an addition to the bookshelves of those of us involved in animal research. It will receive a prominent place in my library.'
Canadian Journal of Anaesthesia, 42:4 (1995)

Authors and Affiliations

  • Cardiovascular and Thoracic, Surgery Research Labs, University of Kentucky, Lexington, USA

    David R. Gross

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