Optimization of Aerosol Drug Delivery

1. Front Matter

   Pages I-IX

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2. A History of the Development of Therapy by Jet Nebulisation

   • Ola Nerbrink

   Pages 1-22

3. Molecular Modeling in Drug Design

   • Bogdan Lesyng, Witold Rudnicki

   Pages 23-48

4. Particle Elaboration Using Supercritical Media for Drug Delivery Into the Human Lungs

   • Jerzy Bałdyga, Marek Henczka

   Pages 49-73

5. Electrospray as Means to Produce Monodisperse Drug Particles

   • Kees B. Geerse, Jan C. M. Marijnissen

   Pages 75-90

6. Optimization of Dry Powder Aerosols for Systemic Drug Delivery

   • Rita Vanbever

   Pages 91-103

7. Recent Advances in Drug Delivery Via Pressured Metered-Dose Inhalers

   • John N. Pritchard

   Pages 105-121

8. Resuspension of Powders and Deposition of Aerosol Particles in the Upper Human Airways

   • Leon Gradoń, Tomasz R. Sosnowski, Arkadiusz Moskal

   Pages 123-137

9. Transport and Deposition of Hydrophilic Drug Particles in the Lungs — Experiment and Theory —

   • Joachim Heyder, Josef Gebhart, Christa Roth, George A. Ferron

   Pages 139-147

10. Ventilation Modelling and Drug Deposition in Very Young Asthmatic Children

    • Frans de Jongh, Rupino Griffioen

    Pages 149-164

11. Modeling Aerosol Drug Delivery

    • Yung Sung Cheng

    Pages 165-188

12. Application of Electro Hydro Dynamic Atomisation in the Production of Engineered Drug Particles

    • Tomasz Ciach, Lidia Diaz, Esther van den IJssel, Jan C. M. Marijnissen

    Pages 189-204

13. Interaction of Deposited Aerosol Particles with the Alveolar Liquid Layer

    • Tomasz R. Sosnowski, Leon Gradoń, Ferry Iskandar, Kikuo Okuyama

    Pages 205-216

14. Pulmonary Deposition and Effects of Aerosolized Drugs in Pulmonary Patients

    • Eric Derom

    Pages 217-242

15. Targetting Aerosols to Disease Areas

    • P. Zanen

    Pages 243-276

16. Treatment of Asthma Patients Under Severe Conditions

    • Giuseppe A. Marraro

    Pages 277-293

17. Understanding the Mechanisms of Local Pulmonary Drug Absorption and Metabolism: An in Vitro Model of the Airway Epithelium

    • Gerrit Borchard

    Pages 295-307

18. Overview

    • Leon Gradoń, Jan Marijnissen

    Pages 309-311

19. Back Matter

    Pages 313-315

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Aerosol therapy has significantly improved the treatment of a variety of respiratory diseases. Besides the treatment of respiratory diseases there is currently also a great interest to use the lungs as a portal to introduce drugs for systemic therapy.
The success of therapy with the application of aerosolized medicaments depends on the possibility to deliver the proper amount of drug to the appropriate sites in the respiratory system, thus limiting the side effects to a minimum. Aerosolized delivery of drugs to the lung is optimized if, for a given chemical composition of a medicine, the target of deposition and the required mass of drug to be deposited are precisely defined.
The next step is the specification of the number of respirable particles or droplets, to be generated by appropriate devices. Another very important factor for successful aerosol therapy is the condition of the patient coupled with his or her inhalation technique.

• Atmen
• asthma
• medicine
• metabolism
• therapy
• transport

• University of Technology, Warsaw, Poland

  Leon Gradoń

• Faculty of Appplied Sciences, Delft University of Technology, Delft, The Netherlands

  Jan Marijnissen

Policies and ethics