Herpesvirus DNA

1. Front Matter

   Pages I-XIV

   PDF

2. Introduction: Current trends in herpesvirus DNA research (a review)

   1. Introduction: Current trends in herpesvirus DNA research (a review)

      • Y. Becker

      Pages 1-10

3. Human Herpesviruses

   1. Herpes simplex virus DNA structure

      1. Structure of HSV-1 DNA at the joint regions

         • Michael J. Wagner, William C. Summers

         Pages 11-26

   2. Transcription of the viral DAN

      1. Immediate-early transcription of HSV-1 and HSV-2

         • J. Barklie Clements, Andrew J. Easton, Frazer J. Rixon

         Pages 27-44

      2. Isolation and characterization of HSV-1 mRNA

         • Edward K. Wagner, Kevin P. Anderson, Robert E. Costa, Gayathri B. Davi, Beverley H. Gaylord, Louis E. Holland et al.

         Pages 45-67

   3. Replication of viral DNA

      1. Properties of the Replicating HSV DNA

         • Ivan Hirsch

         Pages 69-83

      2. Electron microscopy of branched HSV DNA molecules: Possible recombination intermediates

         • Adam Friedmann, Samuel Rabkin, Yechiel Becker

         Pages 85-93

      3. Replication of HSV-1 DNA: Isolation of a subnuclear DNA synthesizing fraction

         • Samuel Rabkin, Yehuda Shtram, Yechiel Becker

         Pages 95-106

   4. Defective viral DNA

      1. Tandem repeat defective DNA from the L segment of the HSV genome

         • Dolores M. Cuifo, Gary S. Hayward

         Pages 107-128

      2. Structure and physical mapping of different classes of defective HSV-1 ANG DNA

         • H. C. Kaerner

         Pages 129-148

      3. Structure and expression of class I and II defective interfering HSV genomes

         • Niza Frenkel, Hilla Locker, Don Vlazny

         Pages 149-184

      4. Biosynthesis of defective HSV DNA

         • Yechiel Becker, Samuel Rabkin

         Pages 185-195

   5. HSV DNA fragments in herpesvirus transformed cells

      1. Mapping of the HSV sequences in transformed cells

         • Jeffrey M. Leiden, Niza Frenkel

         Pages 197-221

      2. Transfection with HSV DNA fragments and DNA from HSV transformed cells

         • G. Darby, K. F. Bastow, A. C. Minson

         Pages 223-253

      3. Viral genes in HSV transformed cells as detected genetically

         • Joan C. M. Macnab

         Pages 255-270

      4. Identification, cloning and sequencing of the HSV thymidine kinase genes

         • G. S. Hayward, G. R. Reyes, E. R. Gavis, S. L. Mcknight

         Pages 271-306

   6. Epstein-Barr virus

      1. Assignment of Epstein-Barr Virus-determined Nuclear Antigen (EBNA) Gene to Chromosome 14 in Human Lymphoblastoid Cells

         • K. Yamamoto, F. Mizuno, T. Matsuo, A. Tanaka, M. Nonoyama, T. Osato

         Pages 307-324

   7. Cytomegalovirus

      1. Organization of the human cytomegalovirus genome

         • J. L. M. C. Geelen, M. W. Weststrate

         Pages 325-343

4. Animal Herpesviruses

   1. DNA of Tupaia Herpesviruses

      • G. Darai, R. M. Flügel, B. Matz, H. Delius

      Pages 345-361

   2. Organization and Replication of Pseudorabies Virus DNA

      • Tamar Ben-Porat, Albert S. Kaplan

      Pages 363-386

Herpesviruses, classified in the family Herpesviridae, are important human and animal pathogens that can cause primary, latent or recurrent infections and even cancer. The major interest in research on herpesviruses today focuses on understanding the organization of the DNA genome, as well as on characterizing the viral genes in regard to their control and function. Modern techniques have allowed the viral DNA to become a molecular tool in the study of gene function, since it is now possible to implant the DNA into eukaryotic cells. This book contains original studies on the structure and organization of the DNA of human and animal herpes­ viruses. The various chapters acquaint the reader with the organization of the viral DNA, the mRNA transcripts, the replicative intermediates of the viral DNA, defective DNA genomes and their mode of synthesis, analyses of the viral DNA sequences in transformed cells, and the relationship between the presence of viral DNA fragments in the cancer cells and the transformed state of the cells.

• Chromosom
• DNA
• electron microscopy
• genes
• microscopy
• transcription

• The Hebrew University of Jerusalem, Jerusalem, Israel

  Yechiel Becker

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