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Radionuclide Imaging in Drug Research

  • Book
  • © 1982

Overview

Editors:
  1. Clive George Wilson

    1. University of Nottingham, Nottingham, UK

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  2. John G. Hardy

    1. Queen’s Medical Centre, Nottingham, UK

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  3. M. Frier

    1. Queen’s Medical Centre, Nottingham, UK

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  4. S. S. Davis

    1. University of Nottingham, Nottingham, UK

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xvi
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  2. Dosage Design — Past, Present and Future

    • D Ganderton
    Pages 1-11

  3. Radiopharmaceutical Targeting in Nuclear Medicine

    • D H Keeling
    Pages 13-20

  4. Data Handling and Computation in Radionuclide Studies

    • D C Barber
    Pages 21-37

  5. Choice of Radionuclides for Scintigraphy

    • J D Kelly
    Pages 39-59

  6. Formulation of Radiopharmaceuticals

    • C R Lazarus
    Pages 61-73

  7. Quality Control of Radiopharmaceuticals

    • M Frier
    Pages 75-83

  8. Radiopharmaceutical Distribution Studies in the Rat

    • Y Jean-Baptiste
    Pages 85-88

  9. Studies of Radiolabelled Preparations in the Rabbit

    • C G Wilson, J G Hardy
    Pages 89-101

  10. The Utilisation of Short-Lived Radionuclides in the Assessment of Formulation and in Vivo Disposition of Drugs

    • G A Digenis
    Pages 103-143

  11. Gastrointestinal Transit of Gamma-Emitting Radionuclide Labelled Preparations

    • J T Fell, E Hunter, H Sharma
    Pages 145-151

  12. Use of Multiple Pinhole External Scintigraphy to Monitor Tablet Disintegration in Vivo

    • M C Theodorakis, M D Devous, D R Simpson
    Pages 153-169

  13. Spreading Characteristics of Proprietary Rectal Steroid Preparations

    • D J Hay
    Pages 171-180

  14. In Vivo Radioimmunodetection of Cancer

    • F H DeLand, E E Kim, D M Goldenberg
    Pages 181-202

  15. Therapeutic Aerosol Deposition

    • S P Newman, D Pavia, S W Clarke
    Pages 203-216

  16. The Evaluation of Parenterally Administered Emulsion Formulations

    • S S Davis, P K Hansrani
    Pages 217-241

  17. In Vivo Distributions of 99mTc-Labelled Liposomes

    • K Jeyasingh
    Pages 243-260

  18. Factors Influencing the Clearance Rates of Colloidal Particles from the Rabbit Knee Joint

    • I W Kellaway, R S Chawla
    Pages 261-277

  19. The Distribution of Radiolabelled Drug in Animals Infected with Cutaneous Leishmaniasis: Comparison of Free and Liposome-Bound Sodium Stibogluconate

    • R R C New, M L Chance, M Critchley
    Pages 279-288

  20. Poster Abstracts

    • M Frier
    Pages 289-326
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Keywords

About this book

The use of gamma-emitting radionuclides for diagnostic imaging in nuclear medicine has been established for many years. Sophisticated gamma ray detecting camera systems and computer links enable the clinical investigator to image different regions of the body and to quantify organ function. Parallel developments have also occurred in the field of radiopharmaceuticals, and today a wide range of products is available that will exhibit specific uptake within target tissues following parenteral administration. For example, radioiodide is taken up by the thyroid and iodinated fatty acids can be used to image the myocardium. Labelled antibodies have been used with success to target certain tumours. The concept of targeting has also been considered by pharmaceutical scientists who wish to deliver drugs rather than radionuclides to specific sites in the body. The systems that have been employed are often physically similar to those used as radiopharmaceuticals (for example colloids, aerosols and liposomes). Furthermore, pioneering work by Digenis and others in the United States States and by Alpsten and co-workers (1976)in Sweden had demonstrated the potential of gamma scintigraphy for investigating the fate of tablets and capsules in the gastrointestinal tract of man in a non­ invasive way. In 1979, the Biopharmaceutics Research Group at Nottingham together with academic pharmacists from Manchester held a one-day syffiposium at Nottingham University to discuss how radio­ nuclides could be used in drug formulation studies to provide better approaches for the delivery of drugs to their sitesof action.

Editors and Affiliations

  • University of Nottingham, Nottingham, UK

    Clive George Wilson, S. S. Davis

  • Queen’s Medical Centre, Nottingham, UK

    John G. Hardy, M. Frier

Bibliographic Information

  • Book Title: Radionuclide Imaging in Drug Research

  • Editors: Clive George Wilson, John G. Hardy, M. Frier, S. S. Davis

  • DOI: https://doi.org/10.1007/978-94-011-9728-1

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: C.G. Wilson, J.G. Hardy, M. Frier and S.S. Davis 1982

  • Softcover ISBN: 978-94-011-9730-4Published: 22 April 2012

  • eBook ISBN: 978-94-011-9728-1Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XVI, 330

  • Topics: Science, Humanities and Social Sciences, multidisciplinary

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