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Auto-Immunity and Auto-Immune Disease

A survey for physician or biologist

  • Book
  • © 1972

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Authors:
  1. Macfarlane Burnet
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Table of contents (15 chapters)

  1. Front Matter

    Pages i-ix
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  2. Introduction

    • Macfarlane Burnet
    Pages 1-8

  3. The stochastic approach to disease

    • Macfarlane Burnet
    Pages 9-32

  4. Modern immunological theory

    • Macfarlane Burnet
    Pages 33-57

  5. Tolerance and paralysis

    • Macfarlane Burnet
    Pages 59-71

  6. Pharmacological aspects of immune responses

    • Macfarlane Burnet
    Pages 73-85

  7. Infection and auto-immunity

    • Macfarlane Burnet
    Pages 87-96

  8. Auto-immune responses in normal animals

    • Macfarlane Burnet
    Pages 97-107

  9. The New Zealand mice

    • Macfarlane Burnet
    Pages 109-119

  10. Diseases primarily involving blood cells

    • Macfarlane Burnet
    Pages 121-129

  11. Generalized auto-immune diseases

    • Macfarlane Burnet
    Pages 131-151

  12. Localized auto-immune diseases

    • Macfarlane Burnet
    Pages 153-171

  13. Pathogenesis of auto-immune disease

    • Macfarlane Burnet
    Pages 173-190

  14. Potentialities and limitations of therapy

    • Macfarlane Burnet
    Pages 191-199

  15. The significance of auto-immunity for ageing

    • Macfarlane Burnet
    Pages 201-212

  16. A programme for the future

    • Macfarlane Burnet
    Pages 213-222

  17. Back Matter

    Pages 223-243
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Keywords

About this book

In 1957 or thereabouts I became impressed with how immunity could be looked at as a process of Darwinian selection amongst the circulating lymphoid cells of the body. The clonal selection theory which grew out of this has been generally accepted in principle by immunologists, but I do not feel that its full implications in relation to pathology have yet been widely realized. In a previous book, Immunological Surveillance, I have tried to apply the approach to cancer immunity. This is a basically similar attempt to look at auto-immune disease from the same Darwinian point of view. Anyone who attempts to produce acceptable general statements about complex biological and clinical phenomena must have a certain sense of guilt. No biological phenomenon can ever be completely, or even adequately, described. There can, at best, only be a progressive improvement in the acceptability, the intellectual elegance, or the practical usefulness of the working generalizations that can be produced. Any attempt to write at this interpretative level can easily be brushed aside as superficial, unnecessary, and liable to be proved wrong or irrelevant by new developments. It is anathema to many good professional scientists and their objections are real enough.

Bibliographic Information

  • Book Title: Auto-Immunity and Auto-Immune Disease

  • Book Subtitle: A survey for physician or biologist

  • Authors: Macfarlane Burnet

  • DOI: https://doi.org/10.1007/978-94-011-8095-5

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Sir Macfarlane Burnet 1972

  • Softcover ISBN: 978-94-011-8097-9Published: 29 April 2012

  • eBook ISBN: 978-94-011-8095-5Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: 243

  • Number of Illustrations: 30 b/w illustrations

  • Topics: Immunology

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