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Radioimmunoassays for Insulin, C-Peptide and Proinsulin

  • Book
  • © 1988

Overview

Authors:
  1. Lise G. Heding

    1. Novo Research Institute, Denmark

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Table of contents (12 chapters)

  1. Front Matter

    Pages I-6
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  2. Introduction

    1. Introduction

      • Lise G. Heding
      Pages 7-8

  3. The establishment of a radioimmunoassay

    1. The establishment of a radioimmunoassay

      • Lise G. Heding
      Pages 9-13

  4. Background for development of improved and new RIAs for insulin, C-peptide and proinsulin

    1. Background for development of improved and new RIAs for insulin, C-peptide and proinsulin

      • Lise G. Heding
      Pages 14-15

  5. Discussion of the methods

    1. Discussion of the methods

      • Lise G. Heding
      Pages 16-24

  6. The present state and expected future development of methods for the determination of β-cell secretory products

    1. The present state and expected future development of methods for the determination of β-cell secretory products

      • Lise G. Heding
      Pages 25-25

  7. Summary and conclusion / Resume og konklusion

    1. Summary and conclusion

      • Lise G. Heding
      Pages 26-28

  8. References

    1. References

      • Lise G. Heding
      Pages 29-35

  10. Back Matter

    Pages 70-83
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Keywords

About this book

THE DISCOVERY OF INSULIN, C-PEPTIDE AND PROINSULlN, SPECIES DIFFERENCES Crude insulin was extracted and isolated from dog pancreases removed 7-1 ° weeks after ligation of the pancreatic duct for the first time in 1921 by Banting and Best. Its lifesaving properties were subsequently documented in pancreatectomized dogs in 1922. Only about six months elapsed from its discovery until systematic collection of calf and ox pancreases and, later, porcine pancreases was established and the blood glucose lowering effect in diabetics using the crude extract from these glands proven. It was not until 1960, however, that the primary structure of all three species of insulin, lO7 human, porcine and bovine, was elucidated . It then became evident that the differences between bovine, porcine and human insulin amounted to at mosl 3 amino acids. These apparently small differences have a significant impact on the physico-chemical characteristics of the three insulins which again affect, e.g., the rate of absorption of insulin lO9 preparations from the subcutaneous tissue and their immunogenicity, i.e.

Authors and Affiliations

  • Novo Research Institute, Denmark

    Lise G. Heding

Bibliographic Information

  • Book Title: Radioimmunoassays for Insulin, C-Peptide and Proinsulin

  • Authors: Lise G. Heding

  • DOI: https://doi.org/10.1007/978-94-011-7094-9

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Lise G. Heding 1988

  • Softcover ISBN: 978-94-011-7096-3Published: 21 March 2012

  • eBook ISBN: 978-94-011-7094-9Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: II, 84

  • Topics: Biochemistry, general, Diabetes

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