Prostaglandins and their Inhibitors in Clinical Obstetrics and Gynaecology

1. Front Matter

   Pages i-xvi

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2. Basic Science

   1. Front Matter

      Pages 1-1

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   2. Bioregulation and mode of action

      • F. A. Kimball, K. T. Kirton

      Pages 3-12

   3. Structure, biosynthesis and metabolism

      • K. Gréen

      Pages 13-26

3. Reproductive Physiology

   1. Front Matter

      Pages 27-27

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   2. The cervix

      • U. Ulmsten

      Pages 29-57

   3. The uterus

      • V. Lundström

      Pages 59-81

   4. The Fallopian tube

      • B. Lindblom

      Pages 83-98

   5. The ovary

      • L. Hamberger, P. O. Janson, L. Nilsson

      Pages 99-108

   6. Implantation

      • N. L. Poyser

      Pages 109-130

   7. Male fertility

      • M. Bygdeman

      Pages 131-142

4. Clinical Applications

   1. Front Matter

      Pages 143-143

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   2. Cervical ripening

      • A. A. Calder

      Pages 145-164

   3. Induction of labour

      • A. P. Lange

      Pages 165-202

   4. Inhibition of labour

      • M. Thiery, J. J. Amy

      Pages 203-231

   5. Postpartum haemorrhage

      • M. K. Toppozada

      Pages 233-251

   6. Abnormal intrauterine pregnancy

      • S. S. Ratnam, R. N. V. Prasad

      Pages 253-270

   7. Induced abortion

      • N. H. Lauersen

      Pages 271-314

   8. Dysmenorrhoea and other menstrual disorders

      • P. T. Russell, O. M. Owens

      Pages 315-334

5. Future Applications

   1. Front Matter

      Pages 335-335

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It is clear today that several prostaglandins play an important role in the regulation of many of the physiological events of the reproductive organs in the human. Both naturally occurring prostaglandins and their analogues are used routinely in many countries to ripen the cervix and induce labour at term as well as to dilate the cervix and to terminate pregnancy. Prostaglandin biosynthesis inhibitors are widely used in the treatment of primary dysmenorrhoea. The editors have aimed at an accurate, thorough, yet easily under­ standable review of the status in 1986 of medical knowledge regarding both the physiological importance and the clinical use of prostaglan­ dins and their inhibitors in obstetrics and gynaecology. I believe this book will be of value for all clinicians concerned with reproductive health. The list of authors guarantees an authoritative and up-to-date review of this active field. SUNE BERGSTROM Karolinska Institutet, Stockholm, Sweden Table Examples of clinical use of natural prostaglandins and some prostaglandin analogues Indications Prostaglandin Route of administration Manufacturer Dilatation of the cervix prior 15-methyl-PGF • Intramuscular Upjohn, USA 2 to vacuum aspiration 16-phenoxy-PGE methyl sulphonylamide Intramuscular Schering AG, West Germany 2 16,16-dimethyl-PGE methyl ester 1 Vaginal ONO, Japan; May & Baker, UK Second trimester abortion Intra -amniotic Upjohn, USA; ONO, Japan PGF 20 Upjohn, USA PGE Vaginal 2 Upjohn, USA 15-methyl-PGF 2.

• ecology
• obstetrics

• Department of Obstetrics and Gynecology, Karolinska Hospital, 01 Stockholm, Sweden

  Marc Bygdeman

• Chapel Hill Fertility Services, Chapel Hill, USA

  Gary S. Berger

• Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, USA

  Louis G. Keith

Policies and ethics