Immunological Aspects of Transplantation Surgery

1. Front Matter

   Pages i-viii

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2. Introduction

   • R. Y. Calne

   Pages 1-3

3. The Morphology of Allograft Reactions

   • B. M. Herbertson

   Pages 4-38

4. Lymphoid Cell Kinetics in Graft-versus-Host Reactions and Allograft Rejection

   • W. L. Ford

   Pages 39-66

5. Chemistry of HL-A Antigen: Separation, Assay and Biological Properties

   • D. A. L. Davies

   Pages 67-91

6. Tissue Typing in Human Kidney Transplantation

   • P. I. Terasaki, G. Opelz, A. Ting

   Pages 92-111

7. Mixed Leukocyte Culture and Cell-Mediated Lympholysis Assays: Models of Allograft Rejection

   • F. H. Bach, Marilyn L. Bach

   Pages 112-135

8. Human Renal Allografts: The Significance of Blocking Factors

   • G. E. Striker, L. J. Quadracci, T. L. Marchioro

   Pages 136-152

9. Immunological Tolerance: The Chimeric State: The Difference Between Full Tolerance and Partial Tolerance

   • Elizabeth Simpson

   Pages 153-190

10. Immunological Enhancement of Transplanted Organs

    • Frank P. Stuart

    Pages 191-213

11. Immunological Engineering and Experimental Transplantation

    • Dennis W. Jirsch, Erwin Diener

    Pages 214-259

12. Kidney and Skin Allografts in the Rat

    • E. White

    Pages 260-278

13. New Possibilities for Organ Allografting in the Mouse

    • Robert J. Corry, Paul S. Russell

    Pages 279-295

14. Allografting in the Pig

    • R. Y. Calne

    Pages 296-316

15. Back Matter

    Pages 339-342

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R. Y.Calne Surgeons are transplanting kidneys in ever increasing numbers-more than 10000 renal allografts have now been reported to the Transplant Registry. With related donors 75% of grafted kidneys continued to function after 2 years, compared with 50% when the donors were unrelated. The therapeutic value is obvious, but the management is largely empirical and results have improved little in the past 5 years. The basic sciences related to tissue transplantation have advanced rapidly. New serological and tissue culture techniques and chemical analysis of antigens and anti­ bodies have produced complicated data that is almost incomprehensible to the non­ specialist. Mathematical treatment of genetic probabilities and of immunological kinetics are similarly difficult to follow for those not especially trained. There has always been a gulf between the practical clinician whose patients do not behave like inbred rodents and the biologist who likes carefully controlled experiments with easily observed results. Both realize, however, that predictable and safe control of rejection must involve close collaboration and co-operation between the laboratory and the clinic. Unfortwlately, the different nature of the work and the workers has widened the gap between them. The clinicians tend to improve their techniques and patient care, whilst the biologists seek clearer and more precisely deflned experi­ ments which lead them to use increasingly artiflcial experimental models.

• surgery
• transplantation

• Department of Surgery, University of Cambridge, Cambridge, England

  Roy Y. Calne

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