Immunological Engineering

1. Front Matter

   Pages i-x

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2. A Biological Approach to the Management of Acute Leukaemia in Man

   • R. L. Powles

   Pages 1-34

3. Biological and Clinical Aspects of Transfer Factor

   • M. P. Arala-Chaves, Maija Horsmanheimo, J. M. Goust, H. Hugh Fudenberg

   Pages 35-82

4. Transfer Factor: Clinical Usage and Experimental Studies

   • A. Basten, S. Croft

   Pages 83-120

5. Manipulation of States of Altered Immunity

   • Richard Hong

   Pages 121-133

6. Immune Response in Cancer Patients

   • R. Mark Vetto

   Pages 135-177

7. Bone Marrow Transplantation

   • D. W. van Bekkum, B. Löwenberg, H. M. Vriesendorp

   Pages 179-227

8. Histocompatibility in Clinical Renal Transplantation

   • Gerhard Opelz

   Pages 229-249

9. HLA Complex—Associations with Disease

   • Nicholas R. StC. Sinclair, Calvin R. Stiller

   Pages 251-285

10. Immunological Manipulations in Renal Allotransplantation

    • Ronald D. Guttmann

    Pages 287-313

11. Solid Tumour Immunotherapy

    • D. W. Jirsch, R. E. Falk

    Pages 315-354

12. Back Matter

    Pages 355-361

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Immunology has become one of the most important of the life sciences. As research unravels the mystery of the lymphocyte, a central role of the immune system in health preservation has become evident. The paediatric immunodeficiency disorders or 'experiments of nature' have demonstrated the division of cellular and humoral immunity; specific functional defects are now readily identified. The tendency of persons with immune dysfunction to develop neoplasms has suggested that surveillance mechanisms within the immune apparatus prevent tumour development. Malignancies, in fact, do seem to provoke certain immune responses, begging numerous therapeutic questions. Transplantation surgery, or the demand for 'new parts' has led to description of those antigens important in tissue-typing. Genetic loci have been found responsible for transplantation antigen display; as well, they influence clinical resistance or susceptibility to a wide variety of infections, auto-immune or neoplastic diseases. Clinicians have been quick to recognize the therapeutic implications of laboratory work and to use this knowledge in disease treatment. Precise patient-tissue matching and immunosuppressive treatment make renal allo­ transplantation safer and more successful than ever before. Both paediatric and adult immune deficiency states are now often recognized; treatment may involve general immune support or specific manipulations with, perhaps, bone marrow or thymus grafts or treatment with lymphocyte transfer factor. Transplantation of bone marrow has been used not only to correct certain immune defects but to correct marrow failure of diverse origin.

• Allotransplantation
• antigen
• diseases
• histocompatibility
• immune response
• immune system
• immunity
• immunodeficiency
• immunology
• immunotherapy
• infection
• resistance
• transplantation

• Department of Surgery, St Michael’s Hospital, University of Toronto, Toronto, Canada

  D. W. Jirsch

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