Immunological Aspects of the Liver and Gastrointestinal Tract

1. Front Matter

   Pages i-xii

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2. The gut-associated lymphoid tissues and gastrointestinal immunity

   • Delphine M. V. Parrott

   Pages 1-32

3. The secretory antibody system

   • Hervé Bazin

   Pages 33-82

4. Gastrointestinal tract and immunodeficiency

   • Hans D. Ochs, Marvin E. Ament

   Pages 83-120

5. Enteric infection and immunization

   • Robert L. Clancy, John Bienenstock

   Pages 121-152

6. Celiac disease and gastrointestinal food allergy

   • Anne Ferguson

   Pages 153-202

7. Autoimmune and inflammatory diseases of the gastrointestinal tract

   • D. P. Jewell, H. J. F. Hodgson

   Pages 203-250

8. The mononuclear phagocytic functions of the liver

   • M. Bjørneboe, Hanne Prytz

   Pages 251-289

9. Aetiological factors in immune-mediated liver disease

   • A. L. W. F. Eddleston

   Pages 291-317

10. Immune mechanisms in liver disease

    • Fiorenzo Paronetto

    Pages 319-343

11. Autoimmune diseases of the liver

    • R. N. M. MacSween, P. A. Berg

    Pages 345-386

12. The role of immunity and hypersensitivity in gut and liver disease: a comparison

    • Ralph Wright

    Pages 387-396

13. Back Matter

    Pages 397-404

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We have been privileged to start our academic careers at the begin­ ning of the decade in which the immunological roles and hypersensitivity diseases of the gastrointestinal tract and liver have been defined. In the early 1960s IgA was reported to be the main secretory immunoglobulin, immunoblasts were shown to home to the intestinal mucosa and certain serum autoantibodies were described in patients with chronic liver disease. Shortly thereafter IgE and Australia antigen were discovered. Parallel advances in clinical investigation, in particular closed biopsy techniques, facilitated correlation of morphological changes with im­ munological mechanisms in disease of the gastrointestinal tract and liver. Only 10 years later, the concepts of immunity and hypersensitivity are regularly applied to the pathogenesis, diagnosis, treatment and prog­ nosis of many chronic diseases in these organs. In designing this book we have attempted to integrate theorectical and clinical immunology as they pertain in 1975; our ultimate aim is aptly described by Brachet as quoted by Professor Paronetto (page 319). We would like to think that this review provides a basis for the next major advances in the fields of gastrointestinal and hepatic immunology. As we see it, the outstanding problem in both sites is how to produce protective immunity without hypersensitivity.

• immunology
• liver
• hepatology

• Gastrointestinal Unit, Western General Hospital Edinburgh and University of Edinburg, UK

  Anne Ferguson

• Department of Pathology, Western Infirmary, Glasgow and University of Glasgow, UK

  Roderick N. M. MacSween

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