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Selected Topics in Mass Spectrometry in the Biomolecular Sciences

  • Book
  • © 1997

Overview

Editors:
  1. Richard M. Caprioli

    1. Medical School, University of Texas, Houston, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Antonio Malorni

    1. SESMA-C.N.R., Napoli, Italy

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    You can also search for this editor in PubMed   Google Scholar

  3. Giovanni Sindona

    1. Dipartimento di Chimica, Arcavacata di Rende, Università della Calabria, Italy

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Nato Science Series C: (ASIC, volume 504)

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Table of contents (30 chapters)

  1. Front Matter

    Pages i-xxvi
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  2. Methods in Mass Spectrometry

    1. Front Matter

      Pages 1-1
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    2. Electrospray Ionization: Theory and Application

      • Simon J. Gaskell, Mark S. Bolgar, Isabel Riba, Scott G. Summerfield
      Pages 3-16

    3. Atmospheric Pressure Ionization (ISI and APCI)

      • A. Raffaelli
      Pages 17-31

    4. Matrix-Assisted Laser Desorption-Ionization (MALDI) Mass Spectrometry: Principles and Applications

      • M. Karas, U. Bahr
      Pages 33-53

    5. High Sensitivity ESI MS and MALDI MS

      • Terry B. Farmer, Richard M. Caprioli
      Pages 55-84

    6. Optimised GC/MS interfacing systems and operating conditions

      • P. J. Arpino
      Pages 85-101

    7. Quantitative Analysis by Mass Spectrometry: Some Important Considerations

      • M. W. Duncan
      Pages 103-119

    8. Optimization of Mass Spectrometric Ionisation Efficiency Data

      • İ. T. Özgen, O. Altungöz, B. Salih, B. G. M. Vandeginste
      Pages 121-127

    9. Role of Internal Energy in Mass Spectrometric Fragmentation

      • Károly Vékey
      Pages 129-142

    10. Interaction of Metal Ions and Protons with Simple Biomolecules. Structure Information from Bond Energies and Entropy Effects

      • B. A. Cerda, M. J. Nold, C. Wesdemiotis
      Pages 143-161

    11. A Promising Marriage Between Theory and Experiment: Density Functional Method Versus Mass Spectrometry

      • T. Marino, N. Russo, E. Sicilia, M. Toscano
      Pages 163-179

  3. Instrumentation for Mass Analysis and Detection

    1. Front Matter

      Pages 181-181
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    2. Recent Advances in Magnet Sector Mass Spectrometry

      • O. V. Nemirovskiy, J. K. Gooden, R. Ramanathan, M. L. Gross
      Pages 183-211

    3. Quadrupole Mass Filters and Quadrupole Ion Traps

      • R. Graham Cooks, Guodong Chen, Carsten Weil
      Pages 213-238

    4. Time-of-Flight Mass Spectrometry

      • Marvin L. Vestal
      Pages 239-262

    5. Combined Analyzer Technologies

      • Peter Kofel, Urs P. Schlunegger
      Pages 263-286

    6. Fourier Transform Mass Spectrometry

      • Michael L. Easterling, I. Jonathan Amster
      Pages 287-314

  4. Application to Biomolecules

    1. Front Matter

      Pages 315-315
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    2. Protein Characterization by MS in the Pharmaceutical Industry

      • D. Müller, P. Schindler, M. Coulot, W. J. Richter, W. Maerki, H. Grossenbacher
      Pages 317-345
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Keywords

About this book

Many fundamental aspects of the methods used in mass spectrometry are here presented by outstanding scientists, with reference to very recent developments. The principles and applications of electrospray, ion spray and MALDI ionization technique are presented, together with optimised GC/MS interfacing systems and tools for quantitative analysis. A comprehensive treatment of modern instrumentation for mass analysis and detection is also included. The major part of the book deals with bioanalytical applications to peptides, proteins, oligonucleotides, polysaccharides, lipids and plant metabolites. Several papers are devoted to the evaluation of adduct formation between DNA and carcinogens. Environmental applications are also included, with examples of some specific cases.
Fundamentals and applications are treated with the same degree of depth: the first two parts of the book therefore provide a basis for the understanding of the biomolecular applications section.
Audience: Ideal for advanced graduate students of chemistry who have learned some basic mass spectrometry. Also useful for Ph.D. students in chemistry, biology and medicine. Of value to researchers in academic and industrial laboratories.

Editors and Affiliations

  • Medical School, University of Texas, Houston, USA

    Richard M. Caprioli

  • SESMA-C.N.R., Napoli, Italy

    Antonio Malorni

  • Dipartimento di Chimica, Arcavacata di Rende, Università della Calabria, Italy

    Giovanni Sindona

Bibliographic Information

  • Book Title: Selected Topics in Mass Spectrometry in the Biomolecular Sciences

  • Editors: Richard M. Caprioli, Antonio Malorni, Giovanni Sindona

  • Series Title: Nato Science Series C:

  • DOI: https://doi.org/10.1007/978-94-011-5165-8

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media Dordrecht 1997

  • Hardcover ISBN: 978-0-7923-4849-8Published: 31 December 1997

  • Softcover ISBN: 978-94-010-6171-1Published: 09 November 2012

  • eBook ISBN: 978-94-011-5165-8Published: 06 December 2012

  • Series ISSN: 1389-2185

  • Edition Number: 1

  • Number of Pages: XXVI, 586

  • Topics: Mass Spectrometry, Analytical Chemistry, Biochemistry, general

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