Physiology And Pharmacology of Cardio-Respiratory Control

1. Front Matter

   Pages i-2

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2. Oxygen Physiology

   1. Enigmas and insights in the oxybiology of high altitude

      • John W. Severinghaus

      Pages 3-10

   2. Possible role of the carotid body responsible for hypoxic ventilatory decline in awake humans

      • H. Kimura, M. Tanaka, K. Nagano, M. Niijima, S. Masuyama, A. Mizoo et al.

      Pages 11-18

   3. Effects of hypoxia and hypercapnia on cardiac contractility and energetics

      • Johannes H. G. M. van Beek

      Pages 19-24

   4. Tissue oxygenation-monitoring using Near Infra Red Spectroscopy

      • Berend Oeseburg

      Pages 25-31

3. Central Chemoreception

   1. Fos immunohistochemistry as a tool to map multisynaptic pathways activated by hypercapnia

      • Luc J. Teppema, J. G. Veening

      Pages 33-37

   2. Cerebral venous PCO2 and hypoxic ventilatory decline

      • Cees N. Olievier

      Pages 39-43

4. Breathing Disorders in Wakefulness and Sleep

   1. End-tidal inspiratory activity and asthma

      • S. C. M. Luijendijk, C. P. M. van der Grinten

      Pages 45-50

   2. Sleep disordered breathing in patients with chronic obstructive pulmonary disease

      • H. Folgering, P. Vos, Y. Heijdra, M. Wagenaar, C. v. Herwaarden

      Pages 51-58

   3. Sleep apnea syndrome as extreme condition of the respiratory control system

      • Joost G. van den Aardweg, Reindert P. van Steenwijk, John M. Karemaker

      Pages 59-63

   4. Children who forget to breathe: the physiological enigma of the congenital central hypoventilation syndrome

      • David Gozal

      Pages 65-74

5. Artificial Ventilation

   1. Alternating versus synchronous ventilation of the two lungs

      • Adrian Versprille, Jos R. C. Jansen

      Pages 75-80

6. Opioids and Anesthetics

   1. (Endogenous) Opioids and the cardiovascular system

      • James G. Bovill

      Pages 81-87

   2. Mechanisms for effects of inhalational anesthetics on control of ventilation

      • Denham S. Ward

      Pages 89-92

   3. Opioid-induced analgesia and respiratory depression: Sex differences

      • Benjamin Kest, Elise Sarton, Jeffrey S. Mogil, Albert Dahan

      Pages 93-100

   4. Separate effects of respiratory stimuli and depressants on abdominal muscle action

      • G. B. Drummond

      Pages 101-108

   5. Influences of low dose volatile anesthetic agents on ventilatory control in humans: a comparison of the Knill and Leiden studies

      • Albert Dahan

      Pages 109-113

7. Modeling Studies

   1. Cardiovascular and pulmonary interactions in pharmacokinetics

      • Jette A. Kuipers, Fred Boer

      Pages 115-120

   2. Pharmacokinetic-pharmacodynamic modeling of sevoflurane-induced respiratory depression in the cat

      • Erik Olofsen, Albert Dahan, Luc Teppema, Elise Sarton, Cees Olievier

      Pages 121-126

   3. An empirical model of the dynamic ventilatory response to hypoxia in normal subjects

      • Patricia M. Warren, Peter K. Wraith

      Pages 127-131

On 15 November 1997, the first international symposium "Neural and Chemical Control of Breathing: Pharmacological and Clinical Aspects" was held at Leiden University Medical Center on the occasion of the retirement of one of the members of the Control of Breathing Research Group of the Departments of Physiology and Anesthesiology, Dr. Aad Berkenbosch. Among others, Dr. Berkenbosch, played an important role in this research group, which made a large and significant contribution to scientific research on the regulation of breathing. This book presents the proceedings of that meeting together with papers of several authors who have strong bonds with the Leiden Departments of Physiology and Anesthesiology. All studies represent state of the art work on the subject of respiratory control and cardiovascular medicine, with emphasis on the physiological, pharmacological and anesthesiological aspects of both fields. The book is divided in several sections: Oxygen Physiology. Prof. John Severinghaus presents among other things his ideas on oxygen sensing and high altitude related diseases. Prof. Honda gives results from studies in a unique set of subjects without carotid bodies. The findings of Honda's group support the idea that an intact hypoxic drive from the carotid bodies is necessary for the generation of central hypoxic depression. Dr. Hans van Beek discusses the effects of hypoxia and hypercapnia on cardiac contractility in animal models. Prof. Oeseburg demonstrates the feasibility of Near Infra Red Oximetry for monitoring tissue oxygenation in patients. Central Chemoreception.

• asthma
• cardiovascular
• cardiovascular system
• depression
• hypoxia
• kinetics
• opioid
• pharmacokinetics
• physiology
• research
• sleep

• Leiden University Medical Center, Leiden, The Netherlands

  Albert Dahan, Luc Teppema

• Free University, Amsterdam, The Netherlands

  Johannes H. G. M. Beek

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