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  • Book
  • © 1998

Liver Growth and Repair

Editors:

  1. Alastair Strain
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    You can also search for this editor in PubMed   Google Scholar

  2. Anne Mae Diehl
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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (25 chapters)

  1. Front Matter

    Pages i-xix
    PDF

  2. Molecular and Cellular Analysis of Liver Growth

    1. Front Matter

      Pages 1-1
      PDF

    2. Liver regeneration following partial hepatectomy: genes and metabolism

      • Nancy L. R. Bucher, Stephen R. Farmer
      Pages 3-27

    4. Epithelial stem-like cells of the rodent liver

      • William B. Coleman, Joe W. Grisham
      Pages 50-99

    5. Transgenic animals as models for hepatocarcinogenesis

      • Eric Santoni-Rugiu, Snorri S. Thorgeirsson
      Pages 100-142

    6. Gene knockout animal models

      • Bonnie Burgess-Beusse, Humberto E. Soriano, Gretchen J. Darlington
      Pages 143-162

    7. Biological activity of growth factors in vivo

      • Kenji Fujiwara, Sumiko Nagoshi
      Pages 163-182

  3. Growth Factors

    1. Front Matter

      Pages 183-183
      PDF

    2. The EGF/TGFα family of growth factors and their receptors

      • William E. Russell, Robert S. Carver
      Pages 185-218

    4. The fibroblast growth factor family

      • Mikio Kan, Wallace L. McKeehan
      Pages 240-260

    5. Growth inhibitory signals and liver regeneration: the TGFβ superfamily

      • Raymond N. DuBois, David Myers, R. Daniel Beauchamp
      Pages 261-282

    6. Cytokines

      • Giuliano Ramadori, Thomas Armbrust
      Pages 283-294

  4. Signaling Events

    1. Front Matter

      Pages 295-295
      PDF

    2. Proto-oncogenes/ transcription factors

      • J. K. Westwick, D. A. Brenner
      Pages 297-310

    3. Cyclins and gap junctions in liver growth and repair

      • Janeen H. Trembley, Betsy T. Kren, Clifford J. Steer
      Pages 311-365

    4. Intracellular signal transduction in liver regeneration

      • Jan B. Hoek, Emanuel Rubin
      Pages 366-401

  5. Biology of the Extracellular Matrix and Non-Parenchymal Cells

    1. Front Matter

      Pages 403-403
      PDF

    2. Proteoglycans

      • Malcolm Lyon
      Pages 405-429
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About this book

Nelson Fausto The Greek myth of Prometheus with its picture of a vulture feasting on its chained victimhas traditionallyprovided a visualimageofliverregeneration. Itis apowerful and frightening representationbut ifone were to substitute the vulture by a surgeon and Prometheus by a patient laying on a properly prepared operating table, the outcomeoftheprocedurewould not differ significantlyfrom that describedbyGreek poets. Yet few of us who work in the field have stopped long enough to ask where this myth originated. Did the poet observe a case of liver regeneration in a human being? Was it brilliant intuition or perhaps, literally, just a 'gut feeling' of a poet looking for good rhymes that led to the prediction that livers grow when part of the tissueisremoved? Thisbookdoesnotattemptto solve these historical issues. Itdoes, instead, cover in detail some of the major modem themes of research on liver regen­ eration, injury and repair. As indicated in Dr. N. Bucher's chapter, the modem phase ofexperimental studies on liver regeneration started in 1931 with the publication by Higgins and Anderson of a method to perform a two-thirds resection of the liver of a rat. The technique described has 3 remarkable features: 1) it is highly reproducible, resulting in the removal of 68% of the liver, 2) it has minimal if any mortality, and 3) it consists only of blood vessel ligation and does not involve cutting through or wounding hepatic tissue.
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Keywords

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Bibliographic Information

  • Book Title: Liver Growth and Repair

  • Editors: Alastair Strain, Anne Mae Diehl

  • DOI: https://doi.org/10.1007/978-94-011-4932-7

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media Dordrecht 1998

  • Hardcover ISBN: 978-0-412-71260-9Published: 31 December 1997

  • Softcover ISBN: 978-94-010-6069-1Published: 08 October 2012

  • eBook ISBN: 978-94-011-4932-7Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XIX, 662

  • Topics: Animal Anatomy / Morphology / Histology, Pathology, Plant Sciences, Surgery

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Buy it now

eBook USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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