Overview
- Editors:
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G. Stacey
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National Institute for Biological Standards and Control, South Mimms, Hertfordshire, UK
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A. Doyle
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Centre for Applied Microbiology and Research, European Collection of Cell Cultures, Salisbury, Wiltshire, UK
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P. Hambleton
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Centre for Applied Microbiology and Research, Salisbury, Wiltshire, UK
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Table of contents (12 chapters)
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- Glyn Stacey, Alan Doyle, David Tyrrell
Pages 1-25
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- John Benbough, B. Andrew Curran
Pages 116-130
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- Bryan Griffiths, Wolfgang Noe
Pages 135-154
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- Christine Rohde, Dieter Claus
Pages 205-222
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Back Matter
Pages 223-244
About this book
It is now more than half a century since animal cells first came into regular use in the laboratory. Instances of laboratory acquired infection and con tamination of therapeutic products, derived from the use of animal cell cultures are rare. The use of animal cells, in addition to an established role in the production of vaccines and therapeutic proteins, has many new medical applications including gene therapy, tissue engineering and cell therapy. Furthermore, C;ldvances in molecular and cell biology are enabling rapid development and application of these technologies and the development of new and more sensitive methods, such as nucleic acid amplification, for the characterisation of cells and the detection of adven titious agents. However, it is clear that there is no room for complacency in this field and the recent expansion in the use of animal cells in the manufacture of medical products and the development of new biological assays for diagnostic and pharmaco-toxicological screening, underlines the need for vigilance regarding the correct and safe use of animal cells as substrates. This book is therefore very timely and should prove to be a highly valuable text, finding a wider audience beyond those with respon sibility for laboratory safety. The book guides the reader from fundamental cell biology issues and the establishment of new in vitro methods, through testing and validation of cell lines and on to issues in the use of animal cells in manufacturing processes.
Reviews
`This book is interesting first at all for biotechnologists and for industrial companies which all should urgently buy this book.'
Cellular and Molecular Biology, 45:4 (1999)
Editors and Affiliations
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National Institute for Biological Standards and Control, South Mimms, Hertfordshire, UK
G. Stacey
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Centre for Applied Microbiology and Research, European Collection of Cell Cultures, Salisbury, Wiltshire, UK
A. Doyle
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Centre for Applied Microbiology and Research, Salisbury, Wiltshire, UK
P. Hambleton
