Bioassay Methods in Natural Product Research and Drug Development

1. Front Matter

   Pages i-x

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2. Plant Biodiversity

   • T. Elmqvist

   Pages 1-9

3. Chemodiversity and the Biological Role of Secondary Metabolites, Some Thoughts for Selecting Plant Material for Drug Development

   • R. Verpoorte

   Pages 11-23

4. Evolving Strategies for the Selection, Dereplication and Prioritization of Antitumor and HIV-Inhibitory Natural Products Extracts

   • John H. Cardellina II, Richard W. Fuller, William R. Gamble, Chandra Westergaard, Jamie Boswell, Murray H. G. Munro et al.

   Pages 25-35

5. Screening Methods for Detection and Evaluation of Biological Activities of Plant Preparations

   • A. J. Vlietinck

   Pages 37-52

6. The use of Receptor Binding, a Very Specific, High Capacity Screening Method, in the Identification of Biologically Active Components from Natural Sources

   • Martin Th. M. Tulp

   Pages 53-65

7. Biological and Chemical Evaluation of Plant Extracts and Subsequent Isolation Strategy

   • A. Marston, K. Hostettmann

   Pages 67-80

8. Natural Products with Antiprotozoal Activity

   • S. L. Croft, C. R. Weiss

   Pages 81-99

9. In-Vitro Assays for Activity-Guided Enrichment of Immunomodulatory Plant Constituents

   • H. van Dijk, C. J. Beukelman, B. H. Kroes, S. B. A. Halkes, H. F. Smit, Linda C. Quarles van Ufford et al.

   Pages 101-111

10. Search for Potent Immunomodulatory Agents from Plants and Other Sources

    • H. Wagner

    Pages 113-118

11. Cyclooxygenase and 5-Lipoxygenase as Targets for Medicinal Plant Research

    • R. Bauer

    Pages 119-141

12. Natural Products in Drug Discovery and Development

    • W. N. A. Rolfsen Sandsborg

    Pages 143-149

13. QPRI’s System for Screening of Natural Products

    • R. J. Quinn

    Pages 151-157

14. Phytera’s Strategy for the Discovery of Novel Anti-Infective Agents from Plant Cell Cultures

    • James B. McAlpine, Christopher Pazoles, Angela Stafford

    Pages 159-166

15. Expediting Drug Development through the Use of Plants

    • Peter J. Hylands

    Pages 167-181

16. The Future Role of Natural Products in Drug Discovery

    • Antony D. Buss

    Pages 183-193

17. Back Matter

    Pages 194-203

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Bioassay Methods in Natural Product Research and Drug Development contains the proceedings from the Phytochemical Society of Europe's very successful symposium on this topic, held August 24-27, 1997 in Uppsala, Sweden.
In this volume, leading academic and industrial scientists discuss novel methods for assaying natural products to find new structure-activity relationships. Of key importance in this process is the availability and reliability of specific bioassay methods, but chapters also discuss chemical and biological diversity and how to dereplicate natural product extracts to increase efficiency in lead discovery.
Anti-tumor, HIV-inhibitory, antiprotozoal, anti-infective and immunomodulatory natural products are discussed. Various industrial projects are presented for the first time.
This volume bridges the gap between academic and industrial research and scientists, and should be required reading in drug companies and faculties of pharmacy, as well as serving scientists in pharmacognosy, pharmacology, phytochemistry, natural products and drug discovery.

• chemistry
• development
• drug
• drug development
• drug discovery
• evolution
• future
• lead
• natural products
• pharmacology
• pharmacy
• plant
• plants
• research

• Division of Pharmacognosy and Centre for Applied Pharmacognosy, Uppsala University, Uppsala, Sweden

  Lars Bohlin, Jan G. Bruhn

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